Art

J-GLOBAL ID：201502201060487273   Reference number：15A1328789

Effects of the endothelin receptor antagonist bosentan on hemodynamics and exercise capacity in Japanese patients with mildly symptomatic pulmonary arterial hypertension

エンドセリン受容体アンタゴニスト ボセンタンの軽度症候性肺動脈高血圧症の日本人患者における循環動態および運動能力への効果

Author (12)： HATANO Masaru (The Univ. of Tokyo, Dep. of Cardiovascular Medicine, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku ...) ,  YAMADA Hidehiro (St. Marianna Univ. School of Medicine, Div. of Rheumatology and Allergy, Dep. of Internal Medicine, Kanagawa, JPN) ,  FUKUDA Keiichi (Keio Univ. School of Medicine, Dep. of Cardiology, Tokyo, JPN) ,  YOSHIOKA Koichiro (Tokai Univ. School of Medicine, Dep. of Cardiovascular Medicine, Kanagawa, JPN) ,  FUNAUCHI Masanori (Kinki Univ. Fac. of Medicine, Dep. of Hematology and Rheumatology, Osaka, JPN) ,  KUWANA Masataka (Keio Univ. School of Medicine, Div. of Rheumatology, Dep. of Internal Medicine, Tokyo, JPN) ,  SATA Masataka (The Univ. of Tokushima Graduate School, Dep. of Cardiovascular Medicine, Inst. of Health Biosciences, Tokushima, JPN) ,  TANIGUCHI Mitsugu (Kinki Univ. Fac. of Medicine, Div. of Cardiology, Osaka, JPN) ,  NAKANISHI Norifumi (National Cerebral and Cardiovascular Center, Div. of Pulmonary Circulation, Dep. of Cardiovascular Medicine, Osaka, JPN) ,  SAITO Takefumi (National Hospital Organization Ibaraki-Higashi National Hospital, Dep. of Respiratory Medicine, Ibaraki, JPN) ,  SAJI Tsutomu (Toho Univ. Omori Medical Center, Dep. of Pediatrics, Tokyo, JPN) ,  SASAYAMA Shigetake (Kyoto Univ., Kyoto, JPN)
Material： Heart and Vessels  (Heart Vessels)
Volume： 30  Issue： 6  Page： 798-804  Publication year： Nov. 2015 
JST Material Number： X0101A  ISSN： 0910-8327  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *pulmonary hypertension ,...
Semi thesaurus term： WHO classification ,...

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JST classification (2)： Clinical application of vasoactive drugs and hypotensive drugs  (GW07050U) ,  Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M)

Substance index (1)： Bosentan

Reference (20)：

• D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT, Levy PS, Pietra GG, Reid LM, Reeves JT, Rich S, Vreim CE, Williams GW, Wu M (1991) Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 115:343-349
• Galiè N, Lj Rubin, Hoeper M, Jansa P, Al-Hiti H, Meyer G, Chiossi E, Kusic-Pajic A, Simonneau G (2008) Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet 371:2093-2100
• Sasayama S, Yoshida K, Okazaki A, Nishimoto S (2012) Results of Japanese post-marketing surveillance of bosentan in pulmonary hypertension (in Japanese). Pharma Medica 30:141-156
• Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaïci A, Weitzenblum E, Cordier JF, Chabot F, Dromer C, Pison C, Reynaud-Gaubert M, Haloun A, Laurent M, Hachulla E, Cottin V, Degano B, Jaïs X, Montani D, Souza R, Simonneau G (2010) Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 122:156-163
• Benza RL, Gomberg-Maitland M, Naeije R, Arneson CP, Lang IM (2011) Prognostic factors associated with increased survival in patients with pulmonary arterial hypertension treated with subcutaneous treprostinil in randomized, placebo-controlled trials. J Heart Lung Transplant 30:982-989

Terms in the title (9)： エンドセリン受容体アンタゴニスト ,  ボセンタン ,  軽度 ,  症候 ,  肺動脈高血圧症 ,  日本人 ,  患者 ,  循環動態 ,  運動能力