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J-GLOBAL ID：201502204445097440   Reference number：15A1273950

分子標的治療を含む併用療法 造血器腫瘍における分子標的治療の耐性と併用療法による克服

Author (1)： MINAMI YOSUKE (神戸大 医 病院 輸血・細胞治療部)
Material： がん分子標的治療  (Journal of Molecular Targeted Therapy for Cancer)
Volume： 13  Issue： 3  Page： 346-351  Publication year： Oct. 09, 2015 
JST Material Number： L5138A  ISSN： 1347-6955  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： rituximab ,...

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JST classification (3)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L)

Substance index (5)： Imatinib ,  Tretinoin ,  Dasatinib ,  Nilotinib ,  PS-341

Reference (11)：

• Dean M, Fojo T, Bates S : Tumour stem cells and drug resistance. Nat Rev Cancer 5 275-284, 2005
• Tomita A, Kiyoi H, Naoe T : Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O 3)in acute promyelocytic leukemia. Int J Hematol 97 717-725, 2013
• Shah NP, Nicoll JM, Nagar B, et al : Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2 : 117-125, 2002
• Apperley JF : Part I ; mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol 8 : 1018-1029, 2007
• Minami Y : Properties of leukemic stem cells and treatment strategy for the cure of chronic myelogenous leukemia. Rinsho Ketsueki 54 : 552-558, 2013

Terms in the title (4)： 分子標的治療 ,  併用療法 ,  造血器腫瘍 ,  耐性