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J-GLOBAL ID：201502206408862717   Reference number：15A1024772

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (IV): phenanthroindolizidine alkaloids from Tylophora tanakae leaves

ヒト成人T細胞白血病/リンパ腫(IV)に対する植物由来の有望な化学療法薬候補のスクリーニング:Tylophora tanakaeの葉由来フェナントロインドリジンアルカロイド

Author (8)： NAKANO Daisuke (Fukuoka Univ., Fac. of Pharmaceutical Sciences, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, JPN) ,  ISHITSUKA Kenji (Fukuoka Univ., Div. of Medical Oncology, Dep. of Internal Medicine, Hematology and Infectious Disease, 7-45-1 ...) ,  IKEDA Mizuki (Fukuoka Univ., Fac. of Pharmaceutical Sciences, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, JPN) ,  TSUCHIHASHI Ryota (Fukuoka Univ., Fac. of Pharmaceutical Sciences, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, JPN) ,  OKAWA Masafumi (Fukuoka Univ., Fac. of Pharmaceutical Sciences, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, JPN) ,  OKABE Hikaru (Fukuoka Univ., Fac. of Pharmaceutical Sciences, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, JPN) ,  TAMURA Kazuo (Fukuoka Univ., Div. of Medical Oncology, Dep. of Internal Medicine, Hematology and Infectious Disease, 7-45-1 ...) ,  KINJO Junei (Fukuoka Univ., Fac. of Pharmaceutical Sciences, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, JPN)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 69  Issue： 3  Page： 397-401  Publication year： Jul. 2015 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *adult T cell leukemia ,...
Semi thesaurus term： Asclepiadaceae ,...

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JST classification (3)： Basic research of antitumor(=antineoplastic)antibiotics  (GX05040Y) ,  Blood cell tumors(=neoplasms)  (GK04000M) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (3)： 3-Demethyl-14-hydroxyisotylocrebrine N-oxide ,  3-Demethyl-14β-hydroxyisotylocrebrine N-oxide ,  Doxorubicin

Reference (9)：

• Ishitsuka K, Tamura K (2008) Treatment of adult T cell leukemia/lymphoma : past, present, and future. Eur J Haematol 80:185–196
• Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda RJ (2010) Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T cell leukemia-lymphoma and peripheral T cell lymphoma. Clin Oncol 28:1591–1598
• Nakano D, Ishitsuka K, Hatsuse T, Tsuchihashi R, Okawa M, Okabe H, Tamura K, Kinjo J (2011) Screening of promising chemotherapeutic candidates against human adult T cell leukemia/lymphoma from plants: active principles structure–activity relationships with withanolides. J Nat Med 65:559–567
• Nakano D, Ishitsuka K, Katsuya H, Kunami N, Nogami R, Yoshimura Y, Matsuda M, Kamikawa M, Tsuchihashi R, Okawa M, Ikeda T, Nohara T, Tamura K, Kinjo J (2012) Screening of promising chemotherapeutic candidates from plants against human adult T cell leukemia/lymphoma (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) against ATL cell lines and structure–activity relationships with withanolides isolated from solanaceous plants. J Nat Med 66:415–420
• Abe F, Iwase Y, Yamauchi T, Honda K, Hayashi N (1995) Phenanthroindolizine alkaloids from Tylophora tanakae. Phytochemistry 39:695–699

Terms in the title (8)： ヒト ,  成人T細胞白血病 ,  リンパ腫 ,  植物 ,  化学療法薬 ,  スクリーニング ,  Tylophora ,  葉