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J-GLOBAL ID：201502209530879867   Reference number：15A0791331

Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases

植物ホルモン,インドール-3-酢酸の誘導体であるミトコン酸5(MA-5)は,ミトコンドリア病の患者からの線維芽細胞の生存を改善する

Author (35)： SUZUKI Takehiro (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  SUZUKI Takehiro (Renal Div., Brigham and Women’s Hospital and Harvard Medical School) ,  YAMAGUCHI Hiroaki (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital) ,  KIKUSATO Motoi (Animal Nutrition, Life Sciences, Graduate School of Agricultural Sci., Tohoku Univ.) ,  MATSUHASHI Tetsuro (Div. of Pediatrics, Tohoku Univ. Graduate School of Medicine) ,  MATSUO Akihiro (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  SATO Takeya (Dep. of Molecular Pharmacology, Tohoku Univ. Graduate School of Medicine) ,  OBA Yuki (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  WATANABE Shun (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  MINAKI Daichi (Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  SAIGUSA Daisuke (Dep. of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku Univ.) ,  SHIMBO Hiroko (Clinical Res. Inst., Kanagawa Children’s Medical Center) ,  MORI Nobuyoshi (Dep. of Internal Medicine and Rehabilitation Sci., Tohoku Univ. Graduate School of Medicine Sendai) ,  MISHIMA Eikan (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  SHIMA Hisato (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  AKIYAMA Yasutoshi (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  TAKEUCHI Yoichi (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  YURI Akinori (Lab. of Oncology, Pharmacy Practice and Sciences, Tohoku Univ. Graduate School of Pharmaceutical Sciences) ,  KIKUCHI Koichi (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  KIKUCHI Koichi (Dep. of Clinical Biology and Hormonal Regulation, Tohoku Univ. Graduate School of Medicine) ,  TOYOHARA Takafumi (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  SUZUKI Chitose (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  KOHZUKI Masahiro (Dep. of Internal Medicine and Rehabilitation Sci., Tohoku Univ. Graduate School of Medicine Sendai) ,  ANZAI Jun-ichi (Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  MANO Nariyasu (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital) ,  KURE Shigeo (Div. of Pediatrics, Tohoku Univ. Graduate School of Medicine) ,  YANAGISAWA Teruyuki (Dep. of Molecular Pharmacology, Tohoku Univ. Graduate School of Medicine) ,  TOMIOKA Yoshihisa (Lab. of Oncology, Pharmacy Practice and Sciences, Tohoku Univ. Graduate School of Pharmaceutical Sciences) ,  TOYOMIZU Masaaki (Animal Nutrition, Life Sciences, Graduate School of Agricultural Sci., Tohoku Univ.) ,  ITO Sadayoshi (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  OSAKA Hitoshi (Div. of Pediatrics, Jichi Medical Univ.) ,  HAYASHI Ken-ichiro (Dep. of Biochemistry, Okayama Univ. of Sci.) ,  ABE Takaaki (Div. of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Univ. Graduate School of Medicine) ,  ABE Takaaki (Dep. of Clinical Biology and Hormonal Regulation, Tohoku Univ. Graduate School of Medicine) ,  ABE Takaaki (Dep. of Medical Sci., Tohoku Univ. Graduate School of Biomedical Engineering)
Material： Tohoku Journal of Experimental Medicine  (Tohoku J Exp Med)
Volume： 236  Issue： 3  Page： 225-232 (J-STAGE)  Publication year： 2015 
JST Material Number： G0649A  ISSN： 0040-8727  CODEN： TJEMAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *mitochondrial disease ,...
Semi thesaurus term： Leigh syndrome ,...

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JST classification (1)： Congenital diseases,deformities in general.  (GD03010V)

Substance index (1)： Indoleacetic acid

Reference (27)：

• Abu Sinna, G. (1983) The effect of the plant hormone indole-3-acetic acid and chemically related compounds on the growth of mouse fibroblast 3T3 cells. Comp. Biochem. Physiol. C, 74, 433-436.
• Avula, S., Parikh, S., Demarest, S., Kurz, J. & Gropman, A. (2014) Treatment of mitochondrial disorders. <i>Curr. Treat. Options Neurol.</i>, 16, 292.
• Carelli, V., La Morgia, C. & Sadun, A.A. (2013) Mitochondrial dysfunction in optic neuropathies: animal models and therapeutic options. <i>Curr. Opin. Neurol.</i>, 26, 52-58.
• Che, R., Yuan, Y., Huang, S. & Zhang, A. (2014) Mitochondrial dysfunction in the pathophysiology of renal diseases. <i>Am. J. Physiol. Renal Physiol.</i>, 306, F367-F378.
• Chung, K.T., Anderson, G.M. & Fulk, G.E. (1975) Formation of indoleacetic acid by intestinal anaerobes. <i>J. Bacteriol.</i>, 124, 573-575.

Terms in the title (9)： 植物ホルモン ,  インドール-3-酢酸 ,  誘導体 ,  ミトコン酸5 ,  MA-5 ,  ミトコンドリア ,  患者 ,  線維芽細胞 ,  生存