Art

J-GLOBAL ID：201502212167983541   Reference number：15A0678580

Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters

アロマターゼをノックアウトしたマウスは,薬物によって誘導されたマウス心電図パラメータの変化がエストロゲンによって強く影響されることを示す

Author (9)： KUROKAWA Junko (Dep. of Bio-Informational Pharmacology, Medical Res. Inst., Tokyo Medical Dental Univ.) ,  SASANO Tetsuo (Dep. of Bio-Informational Pharmacology, Medical Res. Inst., Tokyo Medical Dental Univ.) ,  KODAMA Masami (Dep. of Bio-Informational Pharmacology, Medical Res. Inst., Tokyo Medical Dental Univ.) ,  LI Min (Dep. of Bio-Informational Pharmacology, Medical Res. Inst., Tokyo Medical Dental Univ.) ,  EBANA Yusuke (Dep. of Bio-Informational Pharmacology, Medical Res. Inst., Tokyo Medical Dental Univ.) ,  HARADA Nobuhiro (Dep. of Biochemistry, School of Medicine, Fujita Health Univ.) ,  HONDA Shin-ichiro (Dep. of Biochemistry, School of Medicine, Fujita Health Univ.) ,  NAKAYA Haruaki (Dep. of Pharmacology, Chiba Univ. Graduate School of Medicine) ,  FURUKAWA Tetsushi (Dep. of Bio-Informational Pharmacology, Medical Res. Inst., Tokyo Medical Dental Univ.)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 40  Issue： 3  Page： 339-348 (J-STAGE)  Publication year： 2015 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Potassium Channels ,...
Semi thesaurus term： *HERG channel ,...

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JST classification (4)： Toxicity of chemical substances in general  (GZ02010C) ,  Heart  (EJ04020D) ,  Sex hormones  (EB08050O) ,  Gene manipulation  (EC02050B)

Substance index (1)： E-4031

Reference (40)：

• Bell, J.R., Bernasochi, G.B., Varma, U., Boon, W.C., Ellem, S.J., Risbridger, G.P. and Delbridge, L.M. (2014): Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice. Am. J. Physiol. Heart Circ. Physiol., 306, H1265-74.
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• Carnethon, M.R., Anthony, M.S., Cascio, W.E., Folsom, A.R., Rautaharju, P.M., Liao, D., Evans, G.W. and Heiss, G. (2003): A prospective evaluation of the risk of QT prolongation with hormone replacement therapy: the atherosclerosis risk in communities study. Ann. Epidemiol., 13, 530-536.
• Charbit, B., Christin-Maître, S., Démolis, J.L., Soustre, E., Young, J. and Funck-Brentano, C. (2009): Effects of testosterone on ventricular repolarization in hypogonadic men. Am. J. Cardiol., 103, 887-890.
• Cho, H.S., Takano, M. and Noma, A. (2003): The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node. J. Physiol., 550, 169-180.

Terms in the title (8)： アロマターゼ ,  ノックアウト ,  マウス ,  薬物 ,  誘導 ,  心電図 ,  パラメータ ,  エストロゲン