Art

J-GLOBAL ID：201502212705336978   Reference number：15A0923269

Structural basis for the 4′-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase

微生物チトクロームP450モノオキシゲナーゼによるジクロフェナクの4′ヒドロキシル化の構造基盤

Author (7)： XU Lian-Hua (Zhejiang Univ., Ocean Coll., 866 Yuhangtang Road, 310058, Hangzhou, Zhejiang, CHN) ,  IKEDA Haruo (Kitasato Univ., Kitasato Inst. for Life Sciences, 1-15-1 Kitasato, 252-0373, Sagamihara, Kanagawa, JPN) ,  LIU Ling (Zhejiang Univ., Ocean Coll., 866 Yuhangtang Road, 310058, Hangzhou, Zhejiang, CHN) ,  ARAKAWA Takatoshi (The Univ. of Tokyo, Dep. of Biotechnology, Graduate School of Agriculture and Life Sciences, 1-1-1 Yayoi, Bunkyo-ku ...) ,  WAKAGI Takayoshi (The Univ. of Tokyo, Dep. of Biotechnology, Graduate School of Agriculture and Life Sciences, 1-1-1 Yayoi, Bunkyo-ku ...) ,  SHOUN Hirofumi (The Univ. of Tokyo, Dep. of Biotechnology, Graduate School of Agriculture and Life Sciences, 1-1-1 Yayoi, Bunkyo-ku ...) ,  FUSHINOBU Shinya (The Univ. of Tokyo, Dep. of Biotechnology, Graduate School of Agriculture and Life Sciences, 1-1-1 Yayoi, Bunkyo-ku ...)
Material： Applied Microbiology and Biotechnology  (Appl Microbiol Biotechnol)
Volume： 99  Issue： 7  Page： 3081-3091  Publication year： Apr. 2015 
JST Material Number： H0764A  ISSN： 0175-7598  CODEN： EJABDD  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *cytochrome P450 ,  non-steroidal anti-inflammatory agent ,  affinity ,  coefficient ,  Streptomyces ,  *crystal structure ,  X-ray crystallography ,  *enzyme substrate complex ,  molecular recognition ,  hare ,  species specificity ,  amino acid residue ,  *aromatic chlorine compound ,  amino acid sequence ,  homology(characteristic) ,  aromatic amine ,  aminocarboxylic acid ,  secondary amine ,  *hydroxylation
Semi thesaurus term： *hydroxylation ,  *CYP105D7 ,  CYP2C5 ,  Hill coefficient ,  Streptomyces avermitilis ,  arginine residue ,  binding affinity ,  Xenobiotics

JST classification (3)： Enzyme in general  (EB09010D) ,  Aromatic monocyclic amine,imine,quaternary ammonium,immonium compounds  (CF05050D) ,  Microorganism biochemistry  (EG03020N)

Substance index (1)： Diclofenac

Terms in the title (5)： 微生物 ,  チトクロームP450モノオキシゲナーゼ ,  ジクロフェナク ,  ヒドロキシル化 ,  基盤