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J-GLOBAL ID:201502217030861999   Reference number:15A0942683

Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod Plus Pathogenic Antigen in a Glucose-6-phosphate Isomerase Peptide-Induced Arthritis Mouse Model

グルコース-6-リン酸イソメラーゼペプチド誘発性関節炎マウスモデルにおけるフィンゴリモド+病原抗原の併用処理による疾患進行阻害の機能的機序
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Volume: 38  Issue:Page: 1120-1125 (J-STAGE)  Publication year: 2015 
JST Material Number: S0989A  ISSN: 0918-6158  CODEN: BPBLEO  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: ENGLISH (EN)
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Basic medicine on musculoskeletal system 
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Reference (34):
  • 1) Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet, 376, 1094-1108 (2010).
  • 2) Gumanovskaya ML, Myers LK, Rosloniec EF, Stuart JM, Kang AH. Intravenous tolerization with type II collagen induces interleukin-4- and interleukin-10-producing CD4+ T cells. Immunology, 97, 466-473 (1999).
  • 3) Li H, Ciric B, Yang J, Xu H, Fitzgerald DC, Elbehi M, Fonseca-Kelly Z, Yu S, Zhang GX, Rostami A. Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis. J. Neuroimmunol., 208, 54-60 (2009).
  • 4) Jiang Z, Li H, Fitzgerald DC, Zhang GX, Rostami A. MOG35-55 i.v. suppresses experimental autoimmune encephalomyelitis partially through modulation of Th17 and JAK/STAT pathways. Eur. J. Immunol., 39, 789-799 (2009).
  • 5) Yoshida Y, Tsuji T, Watanabe S, Matsushima A, Matsushima Y, Banno R, Fujita T, Kohno T. Efficacy of combination treatment with fingolimod (FTY720) plus pathogenic autoantigen in a glucose-6-phosphate isomerase peptide (GPI325-339)-induced arthritis mouse model. Biol. Pharm. Bull., 36, 1739-1746 (2013).
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