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J-GLOBAL ID：201502217885210715   Reference number：15A0858870

Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells

ペアードボックス遺伝子5アイソフォームA及びBは未熟B細胞におけるB細胞発生関連遺伝子の転写調節に異なる機能を有する

Author (8)： KIKUCHI Hidehiko ,  NAKAYAMA Masami (Section of Biochemistry and Molecular Biology, Dep. of Medical Sciences, Fac. of Medicine, Univ. of Miyazaki, 5200 ...) ,  KURIBAYASHI Futoshi ,  MIMURO Hitomi (Div. of Bacteriology, Dep. of Infectious Diseases Control, International Res. Center for Infectious Diseases, Inst. ...) ,  IMAJOH-OHMI Shinobu (Lab. Center for Proteomics Res., Graduate School of Frontier Sciences, Inst. of Medical Sci., Univ. of Tokyo, 4-6-1 ...) ,  NISHITOH Hideki (Section of Biochemistry and Molecular Biology, Dep. of Medical Sciences, Fac. of Medicine, Univ. of Miyazaki, 5200 ...) ,  TAKAMI Yasunari (Section of Biochemistry and Molecular Biology, Dep. of Medical Sciences, Fac. of Medicine, Univ. of Miyazaki, 5200 ...) ,  NAKAYAMA Tatsuo (Section of Biochemistry and Molecular Biology, Dep. of Medical Sciences, Fac. of Medicine, Univ. of Miyazaki, 5200 ...)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 59  Issue： 7  Page： 426-431  Publication year： Jul. 2015 
JST Material Number： W1957A  ISSN： 0385-5600  Document type： Article
Article type： 短報  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *DNA binding protein ,...
Semi thesaurus term： genetic regulation ,...

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JST classification (2)： Immunological reaction in general  (ED03010T) ,  Gene expression  (EC02040Q)

Reference (21)：

• Cobaleda C.,Schebesta A., Delogu A., Busslinger M. (2007) Pax5: the guardian Of B cell identity and function. Nat Immunol 8: 463-70.
• Igarashi K., Ochiai K., Muto A. (2007) Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation. J Biochem 141: 783-89.
• Nutt S.L., Urbanek P., Rolink A., Busslinger M. (1997) Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev 11: 476-91.
• Busslinger M. (2004) Transcriptional control of early B cell development. Annu Rev Immunol 22: 55-79.
• Schebesta A., McManus S., Salvagiotto G., Delogu A., Busslinger G.A., Busslinger M. (2007) Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity 27: 49-63.

Terms in the title (4)： 遺伝子 ,  アイソフォーム ,  B細胞 ,  転写調節