Art

J-GLOBAL ID：201502222447803196   Reference number：15A0284714

Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism

色素脱失誘導性フェノール化合物であるロドデンドロールはチロシナーゼ依存的機構を経由してメラニン細胞毒性を発揮する

Author (9)： SASAKI Minoru (Kanebo Cosmetics Inc., Kanagawa, JPN) ,  KONDO Masatoshi (Kanebo Cosmetics Inc., Kanagawa, JPN) ,  SATO Kohji (Kanebo Cosmetics Inc., Kanagawa, JPN) ,  UMEDA Mai (Kanebo Cosmetics Inc., Kanagawa, JPN) ,  KAWABATA Keigo (Kanebo Cosmetics Inc., Kanagawa, JPN) ,  TAKAHASHI Yoshito (Kanebo Cosmetics Inc., Kanagawa, JPN) ,  SUZUKI Tamio (Yamagata Univ. School of Medicine, Yamagata, JPN) ,  MATSUNAGA Kayoko (Fujita Health Univ. School of Medicine, Toyoake, JPN) ,  INOUE Shintaro (Kanebo Cosmetics Inc., Kanagawa, JPN)
Material： Pigment Cell & Melanoma Research  (Pigment Cell Melanoma Res)
Volume： 27  Issue： 5  Page： 754-763  Publication year： Sep. 2014 
JST Material Number： T0984A  ISSN： 1755-1471  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： CCAAT-Enhancer-Binding Proteins ,...

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JST classification (2)： Cosmetics  (YG03030S) ,  Skin diseases  (GF03000Q)

Substance index (3)： rac-4-[(R^*)-3-Hydroxybutyl]phenol ,  rac-4-[(R^*)-3-Hydroxybutyl]-1,2-benzoquinone ,  rac-4-[(R^*)-3-Hydroxybutyl]-1,2-benzenediol

Reference (28)：

• Basma, A.N., Morris, E.J., Nickles, W.J., and Geller, H.M. (1995). L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation. J. Neurochem. 64, 825-832.
• Boissy, R.E., and Manga, P. (2004). On the etiology of contact/occupational vitiligo. Pigment Cell Res. 17, 208-214.
• Bolognia, J.L., Lapia, K., and Somma, S. (2001). Depigmentation therapy. Dermatol. Ther. 14, 29-34.
• Carruthers, W. (1978). Modern Methods of Organic Synthesis. (Cambridge, UK: Cambridge University Press), pp. 407-432.
• Clement, M.V., Long, L.H., Ramalingam, J., and Halliwell, B. (2002). The cytotoxicity of dopamine may be an artefact of cell culture. J. Neurochem. 81, 414-421.

Terms in the title (6)： 色素脱失 ,  フェノール化合物 ,  ロドデンドロール ,  チロシナーゼ ,  メラニン ,  細胞毒性