Art

J-GLOBAL ID：201502241091541994   Reference number：15A0580134

Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia

SLC22A12 (URAT1)機能喪失変異による尿酸の喪失は低尿酸血症で内皮機能障害を生じる

Author (12)： SUGIHARA Shinobu (Div. of Cardiovascular Medicine, Dep. of Molecular Medicine and Therapeutics Fac. of Medicine, Tottori Univ.) ,  HISATOME Ichiro (Dep. of Genetic Medicine and Regenerative Therapeutics, Inst. of Regenerative Medicine and Biofunction, Tottori ...) ,  KUWABARA Masanari (Dep. of Cardiology, St. Luke’s International Hospital) ,  NIWA Koichiro (Dep. of Cardiology, St. Luke’s International Hospital) ,  MAHARANI Nani (Dep. of Genetic Medicine and Regenerative Therapeutics, Inst. of Regenerative Medicine and Biofunction, Tottori ...) ,  KATO Masahiko (Div. of Cardiovascular Medicine, Dep. of Molecular Medicine and Therapeutics Fac. of Medicine, Tottori Univ.) ,  OGINO Kazuhide (Dep. of Clinical Lab., Tottori Univ. Hospital) ,  HAMADA Toshihiro (Dep. of Regional Medicine, Tottori Univ. Fac. of Medicine) ,  NINOMIYA Haruaki (Dep. of Biological Regulation, Tottori Univ. Fac. of Medicine) ,  HIGASHI Yukihito (Dep. of Regeneration and Medicine, Res. Center for Radiation Genome Medicine, Res. Inst. for Radiation Biology and ...) ,  ICHIDA Kimiyoshi (Dep. of Pathophysiology, Tokyo Univ. of Pharmacy and Life science) ,  YAMAMOTO Kazuhiro (Div. of Cardiovascular Medicine, Dep. of Molecular Medicine and Therapeutics Fac. of Medicine, Tottori Univ.)
Material： Circulation Journal  (Circ J)
Volume： 79  Issue： 5  Page： 1125-1132 (J-STAGE)  Publication year： 2015 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *Hypouricaemia ,...

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Congenital diseases,deformities in general.  (GD03010V)

Substance index (1)： Uric Acid

Reference (41)：

• 1. Waring WS, McKnight JA, Webb DJ, Maxwell SR. Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers. Diabetes 2006; 55: 3127-3132.
• 2. Verdecchia P, Schillaci G, Reboldi G, Santeusanio F, Porcellati C, Brunetti P. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension: The PIUMA study. Hypertension 2000; 36: 1072-1078.
• 3. De Leeuw PW, Thijs L, Birkenhäger WH, Voyaki SM, Efstratopoulos AD, Fagard RH, et al; Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Prognostic significance of renal function in elderly patients with isolated systolic hypertension: Results from the Syst-Eur trial. J Am Soc Nephrol 2002; 13: 2213-2222.
• 4. Kuo L, Davis MJ, Cannon MS, Chilian WM. Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation: Restoration of endothelium-dependent responses by L-arginine. Circ Res 1992; 70: 465-476.
• 5. Poredos P. Endothelial dysfunction in the pathogenesis of atherosclerosis. Int Angiol 2002; 21: 109-116.

Terms in the title (5)： URAT1 ,  機能喪失変異 ,  尿酸 ,  低尿酸血症 ,  内皮機能障害