Art

J-GLOBAL ID：201502247974400035   Reference number：15A0542930

A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation

プロリルイソメラーゼPin1の阻害剤のハイスループットスクリーニングは,脂肪細胞分化を低減させる海藻ポリフェノールを同定する

Author (10)： MORI Tadashi (Tohoku Univ., Sendai, JPN) ,  HIDAKA Masafumi (Tohoku Univ., Sendai, JPN) ,  IKUJI Hiroko (Tohoku Univ., Sendai, JPN) ,  YOSHIZAWA Ibuki (Tohoku Univ., Sendai, JPN) ,  TOYOHARA Haruhiko (Kyoto Univ., Kyoto, JPN) ,  OKUDA Toru (Tamagawa Univ., Tokyo, JPN) ,  UCHIDA Chiyoko (Fukushima Univ., Fukushima, JPN) ,  ASANO Tomoichiro (Univ. Hiroshima, Hiroshima, JPN) ,  YOTSU-YAMASHITA Mari (Tohoku Univ., Sendai, JPN) ,  UCHIDA Takafumi (Tohoku Univ., Sendai, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 78  Issue： 5  Page： 832-838  Publication year： May. 2014 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *cis-trans-isomerase ,...
Semi thesaurus term： weight-reducing substance ,...

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JST classification (4)： Marine algae(=seaweeds)  (FJ13030N) ,  Cell physiology in general  (EF02010S) ,  Treatment for metabolic diseases,nutritional diseases.  (GD05030F) ,  Basic research of other drugs acting on metabolism  (GW13060I)

Substance index (1)： 974-B

Reference (22)：

• Takahashi K, Uchida C, Shin RW, Shimazaki K, Uchida T. Prolyl isomerase Pin1: New findings on post-translational modifications and physiological substrates in cancer, Alzheimer's disease and asthma. Cell. Mol. Life Sci. 2008;65:359-375.
• Uchida T, Furumai K, Fukuda T, Akiyama H, Takezawa M, Asano T, Fujimori F, Uchida C. Prolyl Isomerase Pin1 Regulates Mouse Embryonic Fibroblast Differentiation into Adipose Cells. PLoS ONE. 2012;7:e31823.
• Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T. Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model. J. Biol. Chem. 2012;287:44526-44535.
• Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T. Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis. J. Biol. Chem. 2011;286:20812-20822.
• Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Nishimura F, Ogihara T, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T. Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity. J. Biol. Chem. 2010;285:33018-33027.

Terms in the title (8)： プロリルイソメラーゼ ,  Pin1 ,  阻害剤 ,  ハイスループットスクリーニング ,  脂肪細胞分化 ,  海藻 ,  ポリフェノール ,  同定