Art

J-GLOBAL ID：201502276335113688   Reference number：15A0542932

Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells

ラットINS-1β細胞において酸素過剰は糖毒性誘導性のインスリン分泌阻害を逆転させる

Author (11)： MATSUNAGA Tetsuro (Naruto Univ. Education, Naruto, JPN) ,  MATSUNAGA Tetsuro (Kyoto Univ., Kyoto, JPN) ,  LI Shiho (Kyoto Univ., Kyoto, JPN) ,  ADACHI Tetsuya (Kobe Univ., Kobe, JPN) ,  JOO Erina (Kyoto Univ., Kyoto, JPN) ,  GU Ning (Harbin Inst. Technol., Harbin, CHN) ,  YAMAZAKI Hanae (Kyoto Univ., Kyoto, JPN) ,  YAMAZAKI Hanae (Ryukoku Univ., Kyoto, JPN) ,  YASUDA Koichiro (Saiseikai Noe Hospital, Osaka, JPN) ,  KONDOH Takashi (Kyoto Univ., Kyoto, JPN) ,  TSUDA Kinsuke (Kyoto Univ., Kyoto, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 78  Issue： 5  Page： 843-850  Publication year： May. 2014 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： DNA binding ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=15A0542932&from=J-GLOBAL&jstjournalNo=G0021A") }}

JST classification (3)： Pancreas  (EJ06050Y) ,  Metabolism and nutrition of sugar(=glucide)  (EJ02035H) ,  Influence on animals  (EE04040K)

Substance index (1)： Pimonidazole

Reference (47)：

• Bensellam M, Laybutt DR, Jonas JC. The molecular mechanisms of pancreatic beta-cell glucotoxicity: recent findings and future research directions. Mol. Cell. Endocrinol. 2012;364:1-27.
• Jonas JC, Bensellam M, Duprez J, Elouil H, Guiot Y, Pascal SM. Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes. Diabetes. Obes. Metabol. 2009;11:65-81.
• Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr. Rev. 2008;29:351-366.
• Hou ZQ, Li HL, Gao L, Pan L, Zhao JJ, Li GW. Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose. Mol. Cell. Endocrinol. 2008;291:71-78.
• Park KG, Lee KM, Seo HY, Suh JH, Kim HS, Wang L, Won KC, Lee HW, Park JY, Lee KU, Kim JG, Kim BW, Choi HS, Lee IK. Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner. Diabetes. 2007;56:431-437.

Terms in the title (8)： ラット ,  INS ,  β細胞 ,  酸素過剰 ,  糖毒性 ,  インスリン分泌 ,  阻害 ,  逆転