Art

J-GLOBAL ID：201502295534235339   Reference number：15A0743986

NMR-based structural validation of therapeutic antibody produced in Nicotiana benthamiana

Nicotiana benthamianaで生産した治療用抗体のNMRによる構造バリデーション

Author (17)： YAGI Hirokazu (Nagoya City Univ., Nagoya, JPN) ,  FUKUZAWA Noriho (National Inst. Advanced Industrial Sci. and Technol. (AIST), Sapporo, JPN) ,  TASAKA Yasushi (National Inst. Advanced Industrial Sci. and Technol. (AIST), Sapporo, JPN) ,  MATSUO Kouki (National Inst. Advanced Industrial Sci. and Technol. (AIST), Sapporo, JPN) ,  ZHANG Ying (Nagoya City Univ., Nagoya, JPN) ,  ZHANG Ying (National Inst. Natural Sci., Okazaki, JPN) ,  YAMAGUCHI Takumi (Nagoya City Univ., Nagoya, JPN) ,  YAMAGUCHI Takumi (National Inst. Natural Sci., Okazaki, JPN) ,  YAMAGUCHI Takumi (Medical & Biological Lab. Co., Ltd., Nagoya, JPN) ,  KONDO Sachiko (Nagoya City Univ., Nagoya, JPN) ,  KONDO Sachiko (Medical & Biological Lab. Co., Ltd., Nagoya, JPN) ,  NAKAZAWA Shiori (National Inst. Health Sci., Tokyo, JPN) ,  HASHII Noritaka (National Inst. Health Sci., Tokyo, JPN) ,  KAWASAKI Nana (National Inst. Health Sci., Tokyo, JPN) ,  MATSUMURA Takeshi (National Inst. Advanced Industrial Sci. and Technol. (AIST), Sapporo, JPN) ,  KATO Koichi (Nagoya City Univ., Nagoya, JPN) ,  KATO Koichi (National Inst. Natural Sci., Okazaki, JPN)
Material： Plant Cell Reports  (Plant Cell Rep)
Volume： 34  Issue： 6  Page： 959-968  Publication year： Jun. 2015 
JST Material Number： E0975A  ISSN： 0721-7714  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *monoclonal antibody ,  *molecular targeting drug ,  glycoprotein ,  labeling method ,  two-dimensional NMR ,  NMR ,  Nicotiana ,  transgenic tobacco ,  recombinant protein ,  protein synthesis
Semi thesaurus term： Nicotiana Benthamiana ,  *adalimumab ,  stable isotope labeling ,  Heteronuclear Two Dimensional NMR ,  Nuclear Magnetic Resonance, Biomolecular ,  recombinant protein production

JST classification (3)： Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Molecular structure  (EB03020Y) ,  Substance production by plant tissues and cells  (FK03050H)

Terms in the title (5)： Nicotiana ,  治療 ,  抗体 ,  NMR ,  バリデーション