Art

J-GLOBAL ID：201502296949118652   Reference number：15A0726096

Biochemistry of connexins for the ionic homeostasis in cochlea

蝸牛イオン輸送に不可欠なコネキシンによる新たな生化学機構

Author (1)： KAMIYA KAZUSAKU (順天堂大 医 耳鼻咽喉科)
Material： Otology Japan  (Otol Jpn)
Volume： 25  Issue： 2  Page： 119-122  Publication year： May. 25, 2015 
JST Material Number： Y0852B  ISSN： 0917-2025  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： cochlea ,...
Semi thesaurus term： Hereditary deafness

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JST classification (3)： Basic otorhinolaryngology  (GQ01020F) ,  Congenital diseases,deformities in general.  (GD03010V) ,  Auditory sense  (EJ13030M)

Reference (13)：

• Kamiya K, Kaneda M, Sugawara T, et al. : A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. J Neurosci 24 : 2690-2698,2004.
• Nomura N, Kamiya K, Ikeda K, et al. : Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice. Biochem Biophys Res Commun 441 : 544-549,2013.
• Ahmad S, Tang W, Chang Q, et al. : Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness. Proc Natl Acad Sci USA 104 : 1337-1341,2007.
• Qu Y, Tang W, Zhou B, et al. : Early developmental expression of connexin26 in the cochlea contributes to its dominate functional role in the cochlear gap junctions. Biochem Biophys Res Commun 417 : 245-250, 2012.
• Boulay A C, del Castillo F J, Giraudet F, et al. : Hearing is normal without connexin30. J Neurosci 33 : 430-434,2013.

Terms in the title (4)： 蝸牛 ,  イオン輸送 ,  コネキシン ,  生化学