Ayumi Tsutsui

ツツイアユミ | Ayumi Tsutsui

Affiliation and department：
Job title：助教
Other affiliations (1)：

理化学研究所客員研究員

Research field (1)： Bioorganic chemistry

Research keywords (3)：糖化学 , 有機合成化学 , ケミカルバイオロジー

Research theme for competitive and other funds (7)：

2020 - 2023 Investigation of the toxic reduction mechanism by chemical reaction of methylglyoxal with polyamine under the biocondition
2020 - 2021 ポリアミン関与型AGEsの分析方法の確立と食品中での同定
2018 - 2019 Study of enzyme catabolism for polyamine and polyamine_AGEs
2017 - 2019 Derivatization and investigation activity of new anacardic acid analogs from isoleted postia fragilis
2013 - 2014 Biological fanction derived from [4+4] cyclization of polyamine and acrolein

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Papers (12)：

Ayumi Tsutsui, Yuta Morishita, Hiyori Furumachi, Takashi Fujimoto, Rina Hirai, Tomoyuki Fujita, Tomoya Machinami. Generation of cyclic glutathione via the thiolactonization of glutathione and identification of a new radical scavenging mechanism. Tetrahedron Letters. 2021. 68. 152836-152836
Tomoyasu Hirose, Akari Ikeda, Ayumi Tsutsui, Satoshi Ōmura, Toshiaki Sunazuka. Rapid Exploration of Novel Anthelmintic Agents from Alkyne-Bearing Avermectin Derivatives via Click Chemistry. Heterocycles. 2020. 101. 1. 116-125
Ayumi Tsutsui, Ambara R. Pradipta, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka. Effect of spermine-derived AGEs on oxidative stress and polyamine metabolism. ORGANIC & BIOMOLECULAR CHEMISTRY. 2017. 15. 32. 6720-6724
Akihiro Sugawara, Hitomi Maruyama, Sho Shibusawa, Hidehito Matsui, Tomoyasu Hirose, Ayumi Tsutsui, Robrecht Froyman, Carolin Ludwig, Johannes Koebberling, Hideaki Hanaki, et al. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. JOURNAL OF ANTIBIOTICS. 2017. 70. 8. 878-887
Ambara R. Pradipta, Ayumi Tsutsui, Liliya Latypova, Dilyara Chulakova, Ivan Smirnov, Almira Kurbangalieva, Katsunori Tanaka. Unrecognized Cycloaddition Reactions of N-Alkyl-α,β-Unsaturated Imines Occurring in Biosystems and Their Biological Roles. BioNanoScience. 2016. 6. 4. 364-367

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MISC (4)：

Ambara R. Pradipta, Ayumi Tsutsui, Katsunori Tanaka. Unrecognized Reactivity of N-Alkyl Unsaturated Imines: Synthetic Application and Biological Functions. JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN. 2016. 74. 7. 700-709
筒井歩, 座古保, BU Tong, 山口芳樹, 前田瑞夫, 田中克典. ポリアミン由来環化化合物によるアミロイド-β-ペプチドの線維化抑制効果. 日本化学会講演予稿集. 2015. 95th. 4. 1479
筒井歩, PRADIPTA Ambara R., 松本梨沙, 深瀬浩一, 田中克典. 水酸基やアミノ基が活性化する共役イミンの[4+4]環化反応:合成的展開と生体機能制御の可能性. 天然有機化合物討論会講演要旨集(Web). 2013. 55th
Tomoya Machinami, Ayumi Tsutsui, Masaya Kimura, Kazuya Sekihara, Takashi Fujimoto. CARB 109-Aminoacyl sugars as organocatalysts for asymmetric aldol reaction in aqueous media. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008. 235

Lectures and oral presentations (23)：

グルタチオンの環化とラジカル捕捉機能の新規メカニズム
(日本薬学会第140回年会(京都) 2020)
スペルミジンおよびプトレシン型AGEsのモデル体合成と細胞に対する挙動
(日本糖質学会第38回年会(名古屋) 2019)
中高圧処理によって胚乳部へ移行する糠成分について
(日本農芸化学会2019年度大会(東京) 2019)
ポリアミンの生体内化学反応の可能性
(一般社団法人慶応工学会第125回セミナー「現代科学・技術の最前線」~医療・健康維持に向けた有機化学の最前線~(慶應義塾大学)招待講演 2018)
シミタケ(Tyromyces fissilis)由来の新規アナカルジン酸類のがん細胞増殖抑制効果
(第62回TEAC香料・テルペンおよび精油化学に関する討論会(長崎) 2018)

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Professional career (1)：

理学博士

Association Membership(s) (6)：

THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH , THE JAPANESE PEPTIDE SOCIETY , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE CHEMICAL SOCIETY OF JAPAN

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