Art

J-GLOBAL ID：202002282571241271   Reference number：20A0346751

RAPID EXPLORATION OF NOVEL ANTHELMINTIC AGENTS FROM ALKYNE-BEARING AVERMECTIN DERIVATIVES VIA CLICK CHEMISTRY

クリック化学によるアルキン含有アベルメクチン誘導体からの新規駆虫薬の迅速探索

Author (5)： HIROSE Tomoyasu (Kitasato Univ., Tokyo, JPN) ,  IKEDA Akari (Kitasato Univ., Tokyo, JPN) ,  TSUTSUI Ayumi (Kitasato Univ., Tokyo, JPN) ,  OMURA Satoshi (Kitasato Univ., Tokyo, JPN) ,  SUNAZUKA Toshiaki (Kitasato Univ., Tokyo, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 101  Issue： 1  Page： 116-125  Publication year： Jan. 01, 2020 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： Strongylida ,...

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JST classification (3)： Triazoles  (CF07084O) ,  Basic research of antiprotozoan drugs and anthelmintics  (GW17080G) ,  Medical pharmaceuticals for animals  (FE01050B)

Substance index (3)： (2S,3S,4S,6S)-6-{[(2S,3S,4S,6R)-6-[(1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.1^4,8.0^20,24]pentacosane]-10',14',16',22'-tetraen-2'-oneoxy]-4-methoxy-2-methyloxan-3-yl]oxy}-4-methoxy-2-methyloxan-3-yl 4-[4-(4-hydroxybutyl)-1,2,3-triazol-1-yl]benzoate ,  Avermectin B1a ,  Ivermectin B1a

Reference (18)：

• (a) R. W. Burg, B. M. Miller, E. E. Baker, J. Birmbaum, S. A. Currie, R. Hartman, Y.-L. Kong, R. L. Monaghan, G. Olson, I. Putter, J. B. Tunac, H. Wallick, E. O. Stapley, R. Oiwa, and S. Ōmura, Antimicrob. Agents Chemother., 1979, 15, 361; (b) S. Ōmura, In Macrolide Antibiotics - Chemistry, Biology and Practice. 2nd edn., ed. by S. Ōmura, Amsterdam and Boston: Academic Press, 2002, pp. 571-576. And references cited therein.
• R. A. Dybas, In Ivermectin and Abamectin, ed. by W. C. Campbell, Spring-Verlag: New York, 1989, pp. 287-310.
• J. C. Chabala, H. Mrozik, R. L. Tolman, P. Eskola, A. Lusi, L. H. Peterson, M. F. Woods, M. H. Fisher, W. C. Campbell, J. R. Egerton, and D. A. Ostlind, J. Med. Chem., 1980, 23, 1134.
• Q. Shan, J. L. Haddrill, and J. W. Lynch, J. Biol. Chem., 2001, 276, 12556.
• (a) B. M. Greene, K. R. Brown, and H. R. Taylor, In Ivermectin and Abamectin, ed. by W. C. Campbell, Spring-Verlag: New York, 1989, pp. 311-323; (b) O. Zaha, T. Hirata, F. Kinjo, A. Saito, and H. Fukuhara, J. Infect. Chemother., 2002, 8, 94.

Terms in the title (6)： クリック化学 ,  アルキン ,  アベルメクチン ,  誘導体 ,  駆虫薬 ,  探索