Rchr
J-GLOBAL ID:201601002499109403
Update date: Aug. 08, 2024
Hitoshi Nagaoka
ナガオカ ヒトシ | Hitoshi Nagaoka
Affiliation and department:
Gifu University Graduate School of Medicine
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Detailed information
Job title:
Professor
Other affiliations (2):
医学系研究科
教授
連合創薬医療情報研究科
教授
Research field (2):
Immunology
, Medical biochemistry
Research keywords (34):
DNA repair
, immune memory
, lymphocyte
, antibody
, ゲノム医科学
, 免疫反応
, 癌
, 生体分子医学
, IgMb抗体産生
, 発現制御
, 細胞生存維持
, シチジンデアミナーゼ
, 遺伝子組換え
, 細胞周期調節
, S領域
, トランスジェニックマウス
, 細胞内相互作用
, クラススイッチ組換え
, 細胞分化
, 感染症
, 発がん
, ゲノム
, B細胞
, 免疫学
, CD43
, 細胞内局在
, 細胞周期
, 高IgM症候群
, クラススイッチ組み換え
, 免疫
, 抗体遺伝子
, AID
, 遺伝子
, 体細胞突然変異
Research theme for competitive and other funds (24):
2022 - 2025 細胞分裂数を記録する人工遺伝子の開発
2014 - 2017 細胞リプログラミングへのシチジンデアミナーゼの関与
2014 - 2017 細胞リプログラミングへのシチジンデアミナーゼの関与
2014 - 2016 細胞リプログラミングへのシチジンデアミナーゼの関与
2014 - 2016 細胞リプログラミングへのシチジンデアミナーゼの関与
2010 - 2015 Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1
2011 - 2014 Creマウスを用いた新たなin vivo分子機能解析法の確立
2011 - 2014 Creマウスを用いた新たなin vivo分子機能解析法の確立
2011 - 2013 Bリンパ球終末分化機構の解明
2011 - 2013 Creマウスを用いた新たなin vivo分子機能解析法の確立
2011 - 2013 Bリンパ球終末分化機構の解明
2011 - 2013 Analysis of AID expression by a novel Cre-based in vivo gene manipulation system.
2011 - 2012 Bリンパ球終末分化機構の解明
2011 - 抗体記憶の形成・維持機構の解明
2008 - 2011 Molecular mechanisms for class switch recombination and somatic hypermutation of immunoglobulin genes
2005 - 2009 AID-dependent genetic alteration mechanism to generate antigen-specific antibodies
2006 - 2007 抗体遺伝子体細胞突然変異の標的特異性とその破綻
2004 - 2005 The role of AID in class switch recombination and somatic hypermutation of immunoglobulin genes
2004 - 2005 高親和性抗体産生の分子機序
2002 - 2003 抗体遺伝子クラススイッチ組み換え及び体細胞突然変異におけるに於けるAIDの役割
1995 - 1996 Mechanism of B cell maturaion
1995 - 1996 B細胞分化・成熟分子機構の解明及びその制御
1994 - 1996 Functional role of CD43 in immune system
1994 - 1994 B細胞分化・成熟分子機構の解明およびその制御
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Papers (64):
Eka Wahyuni Harlin, Takuya Ito, Shun Nakano, Kohei Morikawa, Katsuya Sato, Masashi Nishikawa, Katsuyuki Nakamura, Hitoshi Nagaoka, Takahiro Nagase, Hiroshi Ueda. Regulation of RHOV signaling by interaction with SH3 domain-containing adaptor proteins and phosphorylation by PKA. Biochemical and Biophysical Research Communications. 2024. 728. 150325-150325
Shun Nakano, Masashi Nishikawa, Rina Asaoka, Natsuko Ishikawa, Chisato Ohwaki, Katsuya Sato, Hitoshi Nagaoka, Hisashi Yamakawa, Takahiro Nagase, Hiroshi Ueda. DBS is activated by EPHB2/SRC signaling-mediated tyrosine phosphorylation in HEK293 cells. Molecular and cellular biochemistry. 2019. 459. 1-2. 83-93
Masashi Nishikawa, Shun Nakano, Hiromu Nakao, Katsuya Sato, Tsuyoshi Sugiyama, Yukihiro Akao, Hitoshi Nagaoka, Hisashi Yamakawa, Takahiro Nagase, Hiroshi Ueda. The interaction between PLEKHG2 and ABL1 suppresses cell growth via the NF-κB signaling pathway in HEK293 cells. Cellular signalling. 2019. 61. 93-107
Srinontong P, Wu Z, Sato K, Nagaoka H, Maekawa Y. The circulating immunoglobulins negatively impact on the parasite clearance in the liver of Leishmania donovani-infected mice via dampening ROS activity. Biochemical and biophysical research communications. 2018
Toshimitsu Ohashi, Mitsuhiro Aoki, Hiroyuki Tomita, Takashi Akazawa, Katsuya Sato, Bunya Kuze, Keisuke Mizuta, Akira Hara, Hitoshi Nagaoka, Norimitsu Inoue, et al. M2-like macrophage polarization in high lactic acid-producing head and neck cancer. CANCER SCIENCE. 2017. 108. 6. 1128-1134
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MISC (13):
Tasuku Honjo, Maki Kobayashi, Nasim Begum, Ai Kotani, Somayeh Sabouri, Hitoshi Nagaoka. The AID Dilemma. Infection, or Cancer?. Advances in Cancer Research. 2012. 113. 1-44
Hitoshi Nagaoka, Thinh Huy Tran, Maki Kobayashi, Masatoshi Aida, Tasuku Honjo. Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity. INTERNATIONAL IMMUNOLOGY. 2010. 22. 4. 227-235
Honjo Tasuku, Nagaoka Hitoshi, Tran Thinh Huy, Nakata Mikiyo, Suzuki Keiichiro, Begum Nasim A, Shinkura Reiko, Fagarasan Sidonia. B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nature Immunology. 2009
TRAN Thinh Huy, 長岡仁, 中田幹代, BEGUM Nasim A, 新藏礼子, 本庶佑. AID遺伝子(Aicda)の発現は,刺激反応性及びBリンパ球特異的な2つのエンハンサー領域とそれに拮抗するサイレンサーにより制御される。. 生化学. 2009. ROMBUNNO.3P-703
Velizar Shivarov, Reiko Shinkura, Tomomitsu Doi, Nasim A. Begum, Hitoshi Nagaoka, Il-Mi Okazaki, Satomi Ito, Taichiro Nonaka, Kazuo Kinoshita, Tasuku Honjo. Molecular mechanism for generation of antibody memory. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 2009. 364. 1517. 569-575
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Lectures and oral presentations (6):
転写因子BATF-IRF4複合体による遺伝子座の高次構造形成とAID遺伝子発現調節
(第91回日本生化学会大会 2018)
CRISPR/Cas9を用いた抗体遺伝子改変酵素AIDの発現調節機構の解析
(BMB2015 2015)
Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age
(国際シンポジウム 細胞運命制御 2012)
抗体遺伝子に免疫記憶を刻む分子AID
(第37回免疫カンファレンス 2011)
RNF8によるPlk1タンパク質の現象とがん細胞における異常
(第84回日本生化学会大会 2011)
more...
Education (2):
1989 - 1993 京都大学医学研究科
1983 - 1989 Yamaguchi University School of Medicine
Professional career (1):
医学博士 (京都大学)
Work history (5):
2011 - 2014 Gifu University
2001/01/01 - 2011/03/31 京都大学医学研究科
1998/04/01 - 2001/03/31 Howard Hughes Medical Institute, the Rockefeller University
1994/04/01 - 2000/03/31 国立感染症研究所
1993/04/01 - 1994/03/31 京都大学医学部付属病院
Association Membership(s) (2):
Japanese Society for Immunology
, The Japanese Biochemical Society
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