HARUKI HORIGUCHI

ホリグチハルキ | HARUKI HORIGUCHI

Affiliation and department：
Homepage URL (1)： http://www.kumamoto-u-molgene.jp

Research field (2)： Tumor biology , Molecular biology

Research keywords (4)：がん , 免疫 , 幹細胞 , 老化

Research theme for competitive and other funds (8)：

2023 - 2026 がん微小環境における細胞間相互作用が織りなすがん免疫制御機構の解明
2023 - 2024 ミトコンドリア機能恒常性と皮膚老化の連関解明
2021 - 2023 がん微小環境におけるANGPTL2を介した細胞間相互作用制御機構の解明
2021 - 2022 がん細胞-微小環境間シグナルクロストークによる腫瘍免疫制御メカニズム􏰂解明
2018 - 2020 The elucidation of the molecular mechanism underlying homeostasis against cancer

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Papers (38)：

Tomoya Yamashita, Haruki Horiguchi, Tsuyoshi Kadomatsu, Michio Sato, Toshiro Moroishi, Yuichi Oike. Immunotherapy-induced reprogramming of cancer-associated fibroblasts can promote tumor progression. Genes to cells. 2024
Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike. Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy. Cancer science. 2024
Taichi Horino, Haruki Horiguchi, Shinsei Yumoto, Tsuyoshi Kadomatsu, Yoshihiro Hara, Taisuke Yagi, Yoshifumi Baba, Yuji Miyamoto, Hideo Baba, Yuichi Oike. Angiopoietin-Like Protein 2 Expression in Tumor Cells Supports Tumor-Associated Macrophage-Induced Tumor Progression in Esophageal Cancer. Annals of surgical oncology. 2024. 31. 12. 7693-7704
Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Yuki Ichigozaki, Toshihiro Kimura, et al. Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy. Cancer gene therapy. 2024
Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, et al. Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine. NPJ vaccines. 2023. 8. 1. 168-168

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MISC (23)：

尾池雄一, 堀口晴紀. Onco-Cardiologyから紐解く心臓irAEの分子基盤解明. 日本心不全学会学術集会プログラム・抄録集. 2023. 27th (CD-ROM)
村上慶高, 中條岳志, 魏范研, 堀口晴紀, 門松毅, 尾池雄一, 安東由喜雄, 植田光晴, 富澤一仁. ミトコンドリアtRNA修飾酵素NSUN3の全身および心臓における生理的意義の解明. 日本生理学雑誌. 2022. 84. 1. 18-19
倉橋竜磨, 原千瑛, 堀口晴紀, 門松毅, 尾池雄一, 神波大己. 転座型腎細胞癌の進行に対するANGPTL2の影響(Effect of ANGPTL2 on the progression of translocation renal cell carcinoma). 西日本泌尿器科学会総会抄録集. 2021. 73回. 168-168
門松毅, 堀口晴紀, 尾池雄一. アンジオポエチン様タンパク質2シグナルを介した細胞間相互作用による抗腫瘍免疫応答制御. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
堀口晴紀, 遠藤元誉, 小田切陽樹, 舛田哲朗, 尾池雄一. 大腸がん細胞の生存におけるANGPTL2の役割(Role of ANGPTL2 in colon cancer cell survival). 日本癌学会総会記事. 2014. 73回. P-3108

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Patents (2)：

Books (1)：

Lectures and oral presentations (9)：

Dual functions of ANGPTL2 in cancer immunity
(第83回日本癌学会学術総会 2024)
加齢に伴うミトコンドリア恒常性の変容と皮膚老化
(第24回日本抗加齢医学会総会 2024)
がん病態におけるANGPTL2の二面性
(第33回日本癌病態治療研究会 2024)
Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity
(2021)
Role of ANGPTL2 in colon cancer cell survival
(第73回日本癌学会学術総会 2014)

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Education (3)：

2011 - 2015 Kumamoto University Graduate School of Medical Sciences
2009 - 2011 Kumamoto University Graduate School of Medical Sciences Graduate School of Medical Sciences
2005 - 2009 Kumamoto Health Science University Faculty of Health Science Dpartment of Medical Technology

Professional career (1)：

Work history (2)：

2020/04 - 現在 Kumamoto University
2015/04 - 2020/03 Kumamoto University Institute of Resource Development and Analysis

Association Membership(s) (4)：

日本分子生物学会 , 日本抗加齢医学会 , 日本生化学会 , THE JAPANESE CANCER ASSOCIATION

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