Yoshioka Kotaro

ヨシオカコウタロウ | Yoshioka Kotaro

Affiliation and department：
Job title： Research Junoir Associate Professor
Homepage URL (1)： http://www.tmd.ac.jp/dept/medicine/nuro/index.html

Research field (1)： Neurology

Research keywords (4)：遺伝子治療 , 核酸医薬 , 神経内科学 , 神経科学

Research theme for competitive and other funds (13)：

2024 - 2028 Size-tunable drug delivery systems for their application to X-ray therapy for brain tumors
2024 - 2027 Development of a treatment for chronic active EB virus infection targeting virus-derived microRNAs
2023 - 2027 Elucidation of novel pathogenic pathways through comprehensive identification of regulatory genes for the autism transcription factor RFX
2023 - 2026 アンチセンス核酸医薬の挑戦的脳デリバリー技術の創生
2022 - 2026 グリオーシス回避を可能とする2本鎖核酸医薬の開発

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Papers (29)：

Natsuki Nakatani, Daisuke Ono, Kosei Hirata, Kotaro Yoshioka, Hironobu Endo, Kenjiro Ono, Makoto Higuchi, Takanori Yokota. [A case of left posterior cortical atrophy presenting with kana-predominant reading impairment]. Rinsho shinkeigaku = Clinical neurology. 2024
Taiki Matsubayashi, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Chunyan Jia, Takao Yamaguchi, Rintaro Iwata Hara, Tetsuya Nagata, Osamu Nakagawa, Satoshi Obika, et al. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2′,4′-BNA/LNA with 9-(aminoethoxy)phenoxazine. Molecular Therapy - Nucleic Acids. 2024. 102161-102161
Kazutaka Nishina, Kotaro Yoshioka, Takanori Yokota, Rintaro Iwata Hara. Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation. Nucleosides, Nucleotides & Nucleic Acids. 2024
Chunyan Jia, Su Su Lei Mon, Ying Yang, Maho Katsuyama, Kie Yoshida-Tanaka, Tetsuya Nagata, Kotaro Yoshioka, Takanori Yokota. Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route. Molecular therapy. Nucleic acids. 2023. 31. 182-196
Takaaki Koide, Shintaro Mandai, Reo Kitaoka, Hisazumi Matsuki, Motoko Chiga, Kouhei Yamamoto, Kotaro Yoshioka, Yohsuke Yagi, Soichiro Suzuki, Tamami Fujiki, et al. Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circulation research. 2023. 132. 4. 415-431

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MISC (21)：

吉岡耕太郎, 横田隆徳. 【核酸医薬と神経疾患】核酸医薬による分子標的メカニズム. Clinical Neuroscience. 2023. 41. 5. 604-607
山田大貴, 吉岡耕太郎, 中山東城, 横田隆徳. 【核酸医薬本領を発揮する創薬モダリティ新たな作用機序を生む核酸のサイエンスから、新薬・ワクチン承認をもたらした核酸修飾・DDS技術、難治性疾患治療への挑戦まで】核酸医薬の新しい潮流希少疾患に対する核酸医薬を用いたN-of-1+創薬. 実験医学. 2021. 39. 17. 2658-2664
吉岡耕太郎. 【核酸医薬本領を発揮する創薬モダリティ新たな作用機序を生む核酸のサイエンスから、新薬・ワクチン承認をもたらした核酸修飾・DDS技術、難治性疾患治療への挑戦まで】(第7章)疾患別神経難病に対する核酸医薬品の開発. 実験医学. 2021. 39. 17. 2834-2840
浅見裕太郎, 吉岡耕太郎, 横田隆徳. 【神経疾患を克服する-わが国の戦略(1)】研究手法の最新の話題核酸医薬. Clinical Neuroscience. 2021. 39. 9. 1114-1118
吉岡耕太郎. 新規2本鎖核酸による遺伝子制御効果・安全性の向上および生体内核酸分子機構の解明. 日本核酸医薬学会誌. 2021. 25. 1. 27-37

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Patents (12)：

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Books (2)：

Lectures and oral presentations (43)：

Expression Profile of EBV-Derived Micro-RNA in Systemic Chronic Active EBV Disease
(64th ASH Annual Meeting & Exposition 2022)
革新的な活性・安全性を有するヘテロ2本鎖核酸医薬の開発
(日本薬学会関東支部第15回若手シンポジウム 2022)
アンチセンス核酸による急性中枢神経毒性の克服に向けて
(日本核酸医薬学会第7回年会シンポジウム01「毒性メカニズムと回避」 2022)
AMPA-receptor-related mechanism of neurotoxicity by antisense oligonucleotides via CSF-route
(Neuro2022 2022)
A novel structure of oligonucleotides improves ASO-efficacy and alleviates acute toxicity in CNS via intracerebroventricular route
(Neuro2022 2022)

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Education (3)：

2012 - 2016 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Cognitive and Behavioral Medicine Neurology and Neurological Science
2001 - 2007 Tokyo Medical and Dental University Faculty of Medicine
Tokyo Medical and Dental University Graduate School, Division of Medicine

Professional career (1)：

Work history (8)：

2024/04 - 現在東京医科歯科大学大学院医歯学総合研究科脳神経病態学分野、統合研究機構・核酸・ペプチド創薬治療研究センター特任講師
2022/04 - 2024/03 Tokyo Medical and Dental University
2020/07 - 2022/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Cognitive and Behavioral Medicine Neurology and Neurological Science Project Assistant Professor
2016/04 - 2020/06 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Cognitive and Behavioral Medicine Neurology and Neurological Science Project Assistant Professor
2012/04 - 2013/03 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Neurology Senior Resident

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Committee career (2)：

Awards (10)：

2023/09 - National Academy of Medicine (NAM) Catalyst Award, Healthy Longevity Global Competition Development of nucleic acid therapeutics with built-in DDS
2022 - ニューヨーク科学アカデミー, 日本医療研究開発機構 Interstellar Initiative Alumni Award
2021 - Oligonucleotide Therapeutics Society Dr. Alan M. Gewirtz Memorial Scholarship Award
2020 - ニューヨーク科学アカデミー, 日本医療研究開発機構 Outstanding Team Presentation Award
2020 - 日本核酸医薬学会奨励賞

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Association Membership(s) (5)：

Oligonucleotide Therapeutics Society , 日本核酸医薬学会 , 日本内科学会 , 日本脳卒中学会 , 日本神経学会

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