Rchr
J-GLOBAL ID：201601010673069370
Update date: Feb. 04, 2023
Akiko Kubo
クボ アキコ | Akiko Kubo
Affiliation and department：
Job title：
Project Senior Assistant Professor / Project Assistant Professor / Project Lecturer
Research field (2)：
Analytical chemistry
, Medical biochemistry
Research keywords (2)：
Metabolomics
, Imaging Mass Spectrometry
Research theme for competitive and other funds (1)：
- 2013 - 2016 メチオニン代謝の可視化によるがん進展におけるエピゲノム制御機構の解明
Papers (29)：
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Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G Kaelin Jr, Makoto Suematsu, et al. Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle. Proceedings of the National Academy of Sciences of the United States of America. 2015. 112. 37. 11642-7
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Toshiki Takenouchi, Yuki Sugiura, Takayuki Morikawa, Tsuyoshi Nakanishi, Yoshiko Nagahata, Tadao Sugioka, Kurara Honda, Akiko Kubo, Takako Hishiki, Tomomi Matsuura, et al. Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015. 35. 5. 794-805
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Mitsuyo Ohmura, Takako Hishiki, Takehiro Yamamoto, Tsuyoshi Nakanishi, Akiko Kubo, Kenji Tsuchihashi, Mayumi Tamada, Sakino Toue, Yasuaki Kabe, Hideyuki Saya, et al. Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry. Nitric Oxide - Biology and Chemistry. 2015. 46. 102-113
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Shogo Yamazoe, Masayuki Naya, Megumi Shiota, Takayuki Morikawa, Akiko Kubo, Takeharu Tani, Takako Hishiki, Tadashi Horiuchi, Makoto Suematsu, Mayumi Kajimura. Large-area surface-enhanced raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays of transparent boehmite. ACS Nano. 2014. 8. 6. 5622-5632
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Takehiro Yamamoto, Naoharu Takano, Kyoko Ishiwata, Mitsuyo Ohmura, Yoshiko Nagahata, Tomomi Matsuura, Aki Kamata, Kyoko Sakamoto, Tsuyoshi Nakanishi, Akiko Kubo, et al. Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. NATURE COMMUNICATIONS. 2014. 5. 3480
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Patents (3)：
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MALDI 用試料調製方法及び試料調製装置
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質量分析を用いたアンモニア測定方法
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分析データ表示処理装置及び表示処理プログラム
Lectures and oral presentations (19)：
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Paradoxical adenylate metabolism in murine ischemic kidney revealed by MALDI-Imaging Mass Spectrometry.
(第89回日本生化学会年会 2016)
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Cystathionine beta-synthase is required for maintaining levels of glutathione hydropersulfide, a novel antioxidant molecule in the murine lens
(第41回日本医用マススペクトル学会年会 2016)
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Dense accumulation of adenosine in the outer stripes of outer medulla in murine kidney identified by microscopic MALDI-imaging mass spectrometry
(21st International Mass Spectrometry Conference 2016)
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Analyses of cell cycle dependent energy management in human colon cancer cells in vivo by imaging mass spectrometry.
(BMB2015 2015)
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担がん組織切片における過硫化グルタチオン蓄積の質量イメージングによる評価
(第63回質量分析総合討論会 2015)
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Professional career (1)：
Work history (4)：
- 2009/04/01 - Keio University, School of Medicine Department of Biochemistry. Project assistant professor
- 2007/02/01 - 2009/03/31 Mitsubishi Institute for Life Sciences 分子加齢医学 研究員
- 2001/10/01 - 2007/03/31 Kyoto University, School of Medicine Department of Cell Biology 研究員
- 1996/10/01 - 2001/09/30 JST ERATO Tsukita Cell Axis Project Researcher
Association Membership(s) (6)：
日本生化学会
, 日本質量分析学会
, 日本医用マススペクトル学会
, 日本細胞生物学会
, The American Society for Cell Biology
, The Society for Neuroscience
