Matsunaga Kohichi

マツナガコウイチ | Matsunaga Kohichi

Affiliation and department：

Research field (1)： Molecular biology

Research keywords (8)：メンブレントラフィック , エキソサイトーシス , インスリン分泌 , オートファジー , Membrane traffic , exocytosis , insulin secretion , autophagy

Research theme for competitive and other funds (17)：

2021 - 2024 表皮水疱症関連タンパク質Exophilin-5における細胞接着装置の制御機構
2019 - 2022 Homeostasis of the epidermal cells and its dysfunction in epidermolysis bullosa
2018 - 2021 Molecular mechanisms of regulation of glucose-stimulated insulin secretion by novel small-molecule activators and inhibitors in pancreatic beta-cells
2015 - 2018 Molecular mechanism of insulin granules exocytosis via the novel Exophilin-8 complexes.
2014 - 2017 Identification of activator of glucose-stimulated insulin secretion by high-throughput chemical screening

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Papers (27)：

Kunli Zhao, Kohichi Matsunaga, Kouichi Mizuno, Hao Wang, Katsuhide Okunishi, Tetsuro Izumi. Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis. eLife. 2023. 12
Keiko Saegusa, Kohichi Matsunaga, Miharu Maeda, Kota Saito, Tetsuro Izumi, Ken Sato. Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells. Communications Biology. 2022. 5. 1
Takafumi Tozawa, Kohichi Matsunaga, Tetsuro Izumi, Naotake Shigehisa, Takamasa Uekita, Masato Taoka, Tohru Ichimura. Ubiquitination-coupled liquid phase separation regulates the accumulation of the TRIM family of ubiquitin ligases into cytoplasmic bodies. PloS one. 2022. 17. 8. e0272700
Miao-Miao Zhao, Jing Lu, Sen Li, Hao Wang, Xi Cao, Qi Li, Ting-Ting Shi, Kohichi Matsunaga, Chen Chen, Haixia Huang, et al. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Nature communications. 2021. 12. 1. 5616-5616
Hameed Abdul, Hafizur Rahman M, Khan M Israr, Jawed Abira, Wang Hao, Zhao Miaomiao, Matsunaga Kohichi, Izumi Tetsuro, Siddiqui Sonia, Khan Faisal, et al. Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway. European journal of pharmacology. 2019. 858

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MISC (32)：

Fushun Fan, Kohichi Matsunaga, Hao Wang, Ray Ishizaki, Eri Kobayashi, Hiroshi Kiyonari, Yoshiko Mukumoto, Katsuhide Okunishi, Tetsuro Izumi. Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa. ELIFE. 2017. 6. e26174
Fushun Fan, Kohichi Matsunaga, Hao Wang, Ray Ishizaki, Eri Kobayashi, Hiroshi Kiyonari, Yoshiko Mukumoto, Katsuhide Okunishi, Tetsuro Izumi. Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa. ELIFE. 2017. 6. e26174
Kohichi Matsunaga, Masato Taoka, Toshiaki Isobe, Tetsuro Izumi. Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2. JOURNAL OF CELL SCIENCE. 2017. 130. 3. 541-550
Kohichi Matsunaga, Masato Taoka, Toshiaki Isobe, Tetsuro Izumi. Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2. Journal of Cell Science. 2017. 130. 3. 541-550
Mami Yamaoka, Tomomi Ando, Takeshi Terabayashi, Mitsuhiro Okamoto, Masahiro Takei, Tomoki Nishioka, Kozo Kaibuchi, Kohichi Matsunaga, Ray Ishizaki, Tetsuro Izumi, et al. PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a. JOURNAL OF CELL SCIENCE. 2016. 129. 3. 637-649

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Books (1)：

Lectures and oral presentations (20)：

メンブレントラフィックによる細胞内物流システムの分子機構
(防衛大学校 GSコロキアム「感染症と安全保障 PartIV」 2019)
Exophilin-8/MyRIP/Slac2C assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa 第70回日本細胞生物学会・第50回日本発生生物学会合同大会ポスター
(第70回日本細胞生物学会・第50回日本発生生物学会合同大会ポスター 2018)
Exophilin-8/MyRIP/Slac2C assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa 第70回日本細胞生物学会・第50回日本発生生物学会合同大会
(第70回日本細胞生物学会・第50回日本発生生物学会合同大会 2018)
新規インスリン分泌促進化合物の分子機構の解明第61回日本糖尿病学会年次学術集会
(第61回日本糖尿病学会年次学術集会 2018)
Roles of the Rab27 effector, Exophilin8/MyRIP, in insulin granule exocytosis.
(The 2nd IMCR symposium on endocrine and metabolism: International Frontiers in Homeostatic Regulation Research in Gunma Univ. 2016)

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Professional career (1)：

Work history (1)：

Awards (1)：

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