Art

J-GLOBAL ID：201602201798982039   Reference number：16A0103800

Angiostatin prevents IL-1β-induced down-regulation of eNOS expression by inhibiting the NF-κB cascade

アンジオスタチンは,IL-1βが誘発するeNOS発現のダウンレギュレーションをNF-κBカスケードを阻害することによって阻止する

Author (11)： KAWASAKI Yasushi (Iwate Medical Univ., Iwate, JPN) ,  YOKOBAYASHI Eriko (Iwate Medical Univ., Iwate, JPN) ,  SAKAMOTO Kentaro (Iwate Medical Univ., Iwate, JPN) ,  TENMA Eri (Iwate Medical Univ., Iwate, JPN) ,  TAKAKI Haruka (Iwate Medical Univ., Iwate, JPN) ,  CHIBA Yuki (Iwate Medical Univ., Iwate, JPN) ,  OTASHIRO Tomomi (Iwate Medical Univ., Iwate, JPN) ,  ISHIHARA Mai (Iwate Medical Univ., Iwate, JPN) ,  YONEZAWA Sei (Iwate Medical Univ., Iwate, JPN) ,  SUGIYAMA Akinori (Iwate Medical Univ., Iwate, JPN) ,  NATORI Yasuhiro (Iwate Medical Univ., Iwate, JPN)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 129  Issue： 3  Page： 200-204 (WEB ONLY)  Publication year： Nov. 2015 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Plasminogen ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (3)： Enzyme in general  (EB09010D) ,  Cell physiology in general  (EF02010S) ,  Basic medicine on cardiovascular system  (GJ01020K)

Reference (15)：

• O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 1994;79:315-328.
• Moulton KS, Vakili K, Zurakowski D, Soliman M, Butterfield C, Sylvin E, et al. Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci U S A. 2003;100:4736-4741.
• Zhang SX, Wang JJ, Lu K, Mott R, Longeras R, Ma JX. Therapeutic potential of angiostatin in diabetic nephropathy. J Am Soc Nephrol. 2006;17:475-486.
• Rabelink TJ, de Boer HC, van Zonneveld AJ. Endothelial activation and circulating markers of endothelial activation in kidney disease. Nat Rev Nephrol. 2010;6:404-414.
• Shinozaki K, Kashiwagi A, Masada M, Okamura T. Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state. J Pharmacol Sci. 2003;91:187-191.

Terms in the title (10)： アンジオスタチン ,  IL-1β ,  誘発 ,  eNOS ,  発現 ,  ダウンレギュレーション ,  NF-κB ,  カスケード ,  阻害 ,  阻止