Art

J-GLOBAL ID：201602208344166665   Reference number：16A0145415

Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides

α-およびβ-フッ素化アミド類の直接的な接触不斉Mannich型反応

Author (6)： BREWITZ Lennart (Inst. of Microbial Chemistry (BIKAKEN), Tokyo, JPN) ,  ARTEAGA Fernando Arteaga (Inst. of Microbial Chemistry (BIKAKEN), Tokyo, JPN) ,  YIN Liang (Inst. of Microbial Chemistry (BIKAKEN), Tokyo, JPN) ,  ALAGIRI Kaliyamoorthy (Inst. of Microbial Chemistry (BIKAKEN), Tokyo, JPN) ,  KUMAGAI Naoya (Inst. of Microbial Chemistry (BIKAKEN), Tokyo, JPN) ,  SHIBASAKI Masakatsu (Inst. of Microbial Chemistry (BIKAKEN), Tokyo, JPN)
Material： Journal of the American Chemical Society  (J Am Chem Soc)
Volume： 137  Issue： 50  Page： 15929-15939  Publication year： Dec. 23, 2015 
JST Material Number： C0254A  ISSN： 0002-7863  CODEN： JACSAT  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Mannich reaction ,  carboxamide ,  imine ,  copper complex ,  copper catalyst ,  chiral ligand ,  *asymmetric synthesis ,  organofluorine compound ,  base (alkali)
Semi thesaurus term： Barton塩基 ,  Mannich-type reaction

JST classification (2)： Addition reaction,elimination reaction  (CF02030M) ,  Stereochemistry of organic reaction  (CF02130V)

Substance index (16)： Benzylidenecarbamic acid tert-butyl ester ,  1-(3,3,3-Trifluoropropanoyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-trifluoromethyl-3-phenyl-3-(Boc-amino)-1-propanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-trifluoromethyl-3-phenyl-3-(Cbz-amino)-1-propanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-trifluoromethyl-3-(2-naphthyl)-3-(Boc-amino)-1-propanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-trifluoromethyl-3-(m-tolyl)-3-(Boc-amino)-1-propanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-trifluoromethyl-3-(p-tolyl)-3-(Boc-amino)-1-propanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-trifluoromethyl-3-(3-vinylphenyl)-3-(Boc-amino)-1-propanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2,3,3,3-tetrafluoro-1-propanone ,  (2R)-1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-fluoro-2-trifluoromethyl-3-phenyl-3-(Boc-amino)-1-propanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-3,3,4,4,4-pentafluoro-1-butanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-(α-(Boc-amino)benzyl)-3,3,4,4,4-pentafluoro-1-butanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-3,3,4,4-tetrafluoro-4-bromo-1-butanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-(α-(Boc-amino)benzyl)-3,3,4,4-tetrafluoro-4-bromo-1-butanone ,  1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-fluoroethanone ,  (2S,3S)-1-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-yl)-2-fluoro-3-phenyl-3-(Boc-amino)-1-propanone

Terms in the title (3)： フッ素化 ,  アミド類 ,  Mannich型反応