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J-GLOBAL ID：201602209680966749   Reference number：16A0200614

Discovery of an intermolecular disulfide bond required for the thermostability of a heterodimeric protein from the thermophile Hydrogenobacter thermophilus

高温菌Hydrogenobacter thermophilusからのヘテロ二量体タンパク質の耐熱性に必要な分子間ジスルフィド結合の発見

Author (4)： KIM Keug Tae (Univ. Tokyo, Tokyo, JPN) ,  CHIBA Yoko (Univ. Tsukuba, Tsukuba, JPN) ,  ARAI Hiroyuki (Univ. Tokyo, Tokyo, JPN) ,  ISHII Masaharu (Univ. Tokyo, Tokyo, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 80  Issue： 2  Page： 232-240  Publication year： Feb. 2016 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *thermophile ,...
Semi thesaurus term： *Hydrogenobacter thermophilus ,...

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JST classification (1)： Proteins and peptides in general  (EB03010N)

Substance index (2)： Cysteine ,  Phosphoserine

Reference (42)：

• Imanaka T, Shibazaki M, Takagi M. A new way of enhancing the thermostability of proteases. Nature. 1986;324:695-697.
• Chakravarty S, Varadarajan R. Elucidation of determinants of protein stability through genome sequence analysis. FEBS Lett. 2000;470:65-69.
• Dominy BN, Minoux H, Brooks CL 3rd. An electrostatic basis for the stability of thermophilic proteins. Proteins. 2004;57:128-141.
• Missimer JH, Steinmetz MO, Baron R, Winkler FK, Kammerer RA, Daura X, van Gunsteren WF. Configurational entropy elucidates the role of salt-bridge networks in protein thermostability. Protein Sci. 2007;16:1349-1359.
• Kumar S, Tsai CJ, Nussinov R. Factors enhancing protein thermostability. Protein Eng. 2000;13:179-191.

Terms in the title (6)： 高温菌 ,  ヘテロ二量体 ,  タンパク質 ,  耐熱性 ,  ジスルフィド結合 ,  発見