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J-GLOBAL ID：201602212144308411   Reference number：16A0258655

Differentiation of rat adipose tissue-derived stem cells into neuron-like cells by valproic acid, a histone deacetylase inhibitor

ヒストンデアセチラーゼ阻害薬であるバルプロ酸による神経細胞様細胞へのラット脂肪組織由来幹細胞の分化

Author (12)： OKUBO Takumi (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  HAYASHI Daiki (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  YAGUCHI Takayuki (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  FUJITA Yudai (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  SAKAUE Motoharu (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  SUZUKI Takehito (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  TSUKAMOTO Atsushi (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  MURAYAMA Ohoshi (School of Life and Environmental Sci., Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  LYNCH Jonathan (School of Life and Environmental Sci., Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  MIYAZAKI Yoko (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  TANAKA Kazuaki (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN) ,  TAKIZAWA Tatsuya (Graduate School of Veterinary Medicine, Azabu Univ., Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, JPN)
Material： Experimental Animals  (実験動物ニュース)
Volume： 65  Issue： 1  Page： 45-51 (J-STAGE)  Publication year： 2016 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： In vitro differentiation ,...

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JST classification (3)： Influence on animals  (EE05040R) ,  Cell physiology in general  (EF02010S) ,  Nervous system in general  (EJ12010J)

Substance index (1)： Valproic acid

Reference (19)：

• 1. Deng W., Obrocka M., Fischer I., and Prockop D.J. 2001. In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem. Biophys. Res. Commun. 282: 148-152.
• 2. Göttlicher M., Minucci S., Zhu P., Krämer O.H., Schimpf A., Giavara S., Sleeman J.P., Lo Coco F., Nervi C., Pelicci P.G., and Heinzel T. 2001. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 20: 6969-6978.
• 3. Gronthos S., Franklin D.M., Leddy H.A., Robey P.G., Storms R.W., and Gimble J.M. 2001. Surface protein characterization of human adipose tissue-derived stromal cells. J. Cell. Physiol. 189: 54-63.
• 4. Grunstein M. 1997. Histone acetylation in chromatin structure and transcription. Nature 389: 349-352.
• 5. Housman T.S., Lawrence N., Mellen B.G., George M.N., Filippo J.S., Cerveny K.A., DeMarco M., Feldman S.R., and Fleischer A.B. 2002. The safety of liposuction: results of a national survey. Dermatol. Surg. 28: 971-978.

Terms in the title (7)： ヒストンデアセチラーゼ阻害薬 ,  バルプロ酸 ,  神経 ,  細胞 ,  ラット ,  脂肪組織由来幹細胞 ,  分化