Art

J-GLOBAL ID：201602212615454316   Reference number：16A0106055

Identification of cysteinylated transthyretin, a predictive biomarker of treatment response to partially hydrolyzed guar gum in type 2 diabetes rats, by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

2型糖尿病ラットにおける,部分的加水分解グアーゴムに対する治療反応の前兆生物マーカーであるシステイン化トランスチレチンの,表面増強レーザ脱離イオン化TOF-MSによる同定

Author (14)： NAITO Yuji (Molecular Gastroenterology and Hepatology, Kyoto Prefectural Univ. of Medicine) ,  ICHIKAWA Hiroshi (Dep. of Medical Life Systems, Fac. of Life and Medical Sciences, Doshisha Univ.) ,  AKAGIRI Satomi (Molecular Gastroenterology and Hepatology, Kyoto Prefectural Univ. of Medicine) ,  UCHIYAMA Kazuhiko (Molecular Gastroenterology and Hepatology, Kyoto Prefectural Univ. of Medicine) ,  TAKAGI Tomohisa (Molecular Gastroenterology and Hepatology, Kyoto Prefectural Univ. of Medicine) ,  HANDA Osamu (Molecular Gastroenterology and Hepatology, Kyoto Prefectural Univ. of Medicine) ,  YASUKAWA Zenta (Nutrition Div., Taiyo Kagaku Co., Ltd.) ,  TOKUNAGA Makoto (Nutrition Div., Taiyo Kagaku Co., Ltd.) ,  ISHIHARA Noriyuki (Nutrition Div., Taiyo Kagaku Co., Ltd.) ,  OKUBO Tsutomu (Nutrition Div., Taiyo Kagaku Co., Ltd.) ,  MUKAI Jun (Biomarker Sci. Co., Ltd.) ,  OHKI Makoto (Biomarker Sci. Co., Ltd.) ,  UCHIDA Kagehiro (Biomarker Sci. Co., Ltd.) ,  YOSHIKAWA Toshikazu (Molecular Gastroenterology and Hepatology, Kyoto Prefectural Univ. of Medicine)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 58  Issue： 1  Page： 23-33 (J-STAGE)  Publication year： 2016 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： experimental disease ,...
Semi thesaurus term： *time of flight mass spectrometry ,...

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JST classification (2)： Medical instruments and apparatuses  (GA05020L) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Reference (60)：

• 1 Pathak M. Diabetes mellitus type 2 and functional foods of plant origin. Recent Pat Biotechnol 2014; 8: 160-164.
• 2 Minamiyama Y, Bito Y, Takemura S, et al. Calorie restriction improves cardiovascular risk factors via reduction of mitochondrial reactive oxygen species in type II diabetic rats. J Pharmacol Exp Ther 2007; 320: 535-543.
• 3 Rector RS, Thyfault JP, Morris RT, et al. Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol 2008; 294: G619-G626.
• 4 Song KH, Lee WJ, Koh JM, et al. alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun 2005; 326: 197-202.
• 5 Minamiyama Y, Takemura S, Tsukioka T, et al. Effect of AOB, a fermented-grain food supplement, on oxidative stress in type 2 diabetic rats. Biofactors 2007; 30: 91-104.

Terms in the title (11)： 2型糖尿病 ,  ラット ,  加水分解 ,  グアーゴム ,  治療反応 ,  前兆 ,  生物マーカー ,  システイン ,  トランスチレチン ,  表面増強レーザ脱離イオン化TOF-MS ,  同定