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J-GLOBAL ID：201602213031259011   Reference number：16A0092651

Antidepressive-like effect of a Kampo (traditional Japanese) medicine, kososan (Xiang Su San) in a stress-induced depression-like mouse model: Proteomic analysis of hypothalamus

ストレス誘導性鬱病様マウスモデルにおける漢方(伝統的日本)薬であるコソウサン(香蘇散)の抗鬱様効果:視床下部のプロテオミクス分析

Author (10)： NAGAI Takayuki (Kitasato Univ., Tokyo, JPN) ,  HASHIMOTO Ryoko (Kitasato Univ., Tokyo, JPN) ,  OKUDA Sari M. (Kitasato Univ., Tokyo, JPN) ,  KODERA Yoshio (Kitasato Univ., Kanagawa, JPN) ,  OH-ISHI Masamichi (Kitasato Univ., Kanagawa, JPN) ,  MAEDA Tadakazu (Kitasato Univ., Kanagawa, JPN) ,  ITO Naoki (Kitasato Univ., Tokyo, JPN) ,  HANAWA Toshihiko (Kitasato Univ., Tokyo, JPN) ,  KIYOHARA Hiroaki (Kitasato Univ., Tokyo, JPN) ,  YAMADA Haruki (Kitasato Univ., Tokyo, JPN)
Material： Traditional & Kampo Medicine  (Tradit Kampo Med)
Volume： 2  Issue： 2  Page： 50-59  Publication year： Sep. 2015 
JST Material Number： Y0941B  ISSN： 2053-4515  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *Koso-san ,...

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JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of psychotropic drugs  (GW03100Y)

Substance index (1)： LY-341495

Reference (27)：

• Hanawa T. Kososan and Hangekobokuto. J. Kampo Med. 1995; 42: 418-426.
• Ito N, Nagai T, Yabe T, Nunome S, Hanawa T, Yamada H. Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis. Phytomedicine 2006; 13: 658-667.
• Nagai T, Narikawa T, Ito N, Takeda T, Hanawa T, Yamada H. Antidepressant-like effect of a Kampo (Japanese herbal) medicine, kososan, against the interferon-α-induced depressive-like model mice. J. Tradit. Med. 2008; 25: 74-80.
• Ito N, Yabe T, Nagai T, Oikawa T, Yamada H, Hanawa T. A possible mechanism underlying an antidepressive-like effect of Kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice. Biol. Pharm. Bull. 2009; 32: 1716-1722.
• Ito N, Hori A, Yabe T et al. Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice. Biol. Pharm. Bull. 2012; 35: 1775-1783.

Terms in the title (11)： ストレス ,  鬱病 ,  マウスモデル ,  漢方 ,  日本 ,  薬 ,  香蘇散 ,  鬱 ,  視床下部 ,  プロテオミクス ,  分析