Art

J-GLOBAL ID：201602220877066224   Reference number：16A1175949

Unfavorable neuroblastoma prognostic factor NLRR2 inhibits cell differentiation by transcriptional induction through JNK pathway

不良な神経芽腫予後因子NLRR2はJNK経路を通して転写を誘導することで細胞分化を阻害する

Author (9)： Sheikh Afzal (Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Sheikh Afzal (Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan) ,  Takatori Atsushi (Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan. [e-mail]) ,  Takatori Atsushi (Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan. [e-mail]) ,  Hossain Md Shamim (Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Hasan Md Kamrul (Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Tagawa Masatoshi (Division of Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Nagase Hiroki (Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Nakagawara Akira (Saga-Ken Medical Center Koseikan, Saga, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 107  Issue： 9  Page： 1223-1232  Publication year： 2016 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： DNA binding protein ,...
Semi thesaurus term： c-Jun ,...

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Author keywords (5)： c-Jun ,  differentiation ,  JNK ,  neuroblastoma ,  NLRR2

JST classification (3)： Tumors(=neoplasms)of nervous system  (GN04000V) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Biological function  (EB03040U)

Substance index (1)： Tretinoin

Reference (40)：

• Chang HH, Lee H, Hu MK et al. Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma. Clin Cancer Res 2010; 16: 4411-20.
• Brodeur GM, Nakagawara A. Molecular basis of clinical heterogeneity in Neuroblastoma. Am J Pediatr Hematol Oncol 1992; 14: 111-6.
• John M, Maris MD. Recent advances in neuroblastoma. N Engl J Med 2010; 362: 2202-11.
• Nakagawara A, Arima M, Azar CG, Scavarda NJ, Brodeur GM. Inverse relationship between trk expression and N-myc amplification in human neuroblastomas. Cancer Res 1992; 52: 1364-8.
• Chen Y, Takita J, Choi YL et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature 2008; 16: 971-4.

Terms in the title (8)： 神経芽腫 ,  予後因子 ,  JNK ,  経路 ,  転写 ,  誘導 ,  細胞分化 ,  阻害