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J-GLOBAL ID：201602221695406138   Reference number：16A1169092

Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells

培養血管内皮細胞における,メタロチオネイン誘導物質としてのジエチルジチオカルバミン酸亜鉛

Author (10)： Fujie Tomoya (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Segawa Yukino (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Uehara Akane (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Nakamura Takehiro (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Kimura Tomoki (Department of Life Science, Faculty of Science and Engineering, Setsunan University) ,  Yoshida Eiko (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Yamamoto Chika (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University) ,  Uchiyama Masanobu (Graduate School of Pharmaceutical Sciences, University of Tokyo) ,  Naka Hiroshi (Graduate School of Science and Research Center for Materials Science, Nagoya University) ,  Kaji Toshiyuki (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 41  Issue： 2  Page： 217-224(J-STAGE)  Publication year： 2016 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *metallothionein ,...
Semi thesaurus term： MTF-1 ,...

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Author keywords (6)： Antioxidant response element ,  Metallothionein ,  Metal response element ,  Vascular endothelial cell ,  Zinc ,  Zinc complex

JST classification (4)： Gene expression  (EC02040Q) ,  Toxicity of inorganic compounds in general  (GZ02021E) ,  Cell physiology in general  (EF02010S) ,  Basic medicine on cardiovascular system  (GJ01020K)

Reference (38)：

• Bittel, D., Dalton, T., Samson, S.L., Gedamu, L. and Andrews, G.K. (1998): The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals. J. Biol. Chem., 273, 7127-7133.
• Dalton, T., Palmiter, R.D. and Andrews, G.K. (1994): Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucleic Acids Res., 22, 5016-5023.
• Early, J.L. and Schnell, R.C. (1978): Zinc-induced protection against cadmium alteration of drug action. Res. Commun. Chem. Pathol. Pharmacol., 19, 369-372.
• Esmon, C.T., Esmon, N.L. and Harris, K.W. (1982): Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J. Biol. Chem., 257, 7944-7947.
• Fagerberg, B., Bergström, G., Borén, J. and Barregard, L. (2012): Cadmium exposure is accompanied by increased prevalence and future growth of atherosclerotic plaques in 64-year-old women. J. Intern. Med., 272, 601-610.

Terms in the title (5)： 培養 ,  血管内皮細胞 ,  メタロチオネイン ,  ジエチルジチオカルバミン酸 ,  亜鉛