Art

J-GLOBAL ID：201602227433458625   Reference number：16A1196810

Phosphonocarboxylates Can Protect Mice against the Inflammatory and Necrotic Side Effects of Nitrogen-Containing Bisphosphonates by Inhibiting Their Entry into Cells via Phosphate Transporters

ホスホノカルボン酸はリン酸トランスポーターを介する細胞への窒素含有ビスホスホネートの流入を阻害することにより,これらの炎症および壊死性副作用からマウスを保護することができる

Author (9)： Kiyama Tomomi (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University) ,  Kiyama Tomomi (Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University) ,  Tsuchiya Masahiro (Division of Aging and Geriatric Dentistry, Graduate School of Dentistry, Tohoku University) ,  Okada Satoru (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University) ,  Oizumi Takefumi (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University) ,  Yamaguchi Kouji (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University) ,  Sasaki Keiichi (Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University) ,  Sugawara Shunji (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University) ,  Endo Yasuo (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 39  Issue： 5  Page： 712-720(J-STAGE)  Publication year： 2016 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： *ホスホノカルボン酸 ,...

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Author keywords (10)： phosphonocarboxylate ,  bisphosphonate side effect ,  phosphate transporter ,  phosphonoacetate ,  phosphonoformate ,  phosphonocarboxylate ,  bisphosphonate side effect ,  phosphate transporter ,  phosphonoacetate ,  phosphonoformate

JST classification (1)： Basic research of other drugs  (GW23010K)

Substance index (9)： Etidronate ,  Clodronate ,  Foscarnet ,  Phosphonoacetic Acid ,  3-Phosphonopropionic acid ,  4-Phosphonobutyric acid ,  Alendronate ,  Zoledronate ,  YM-529

Reference (41)：

• 1) Geddes AD, D’Souza SM, Ebetino FH, Kenneth JI. Bisphosphonates: structure-activity relationships and therapeutic implications. Bone and Mineral Research. (Heershe NM, Kanis JK eds.) Vol. 8, Elsevier Science BV, Amsterdam, Holland, pp. 265-306 (2005).
• 2) Rogers MJ, Crockett JC, Coxon FP, Mönkkönen J. Biochemical and molecular mechanisms of action of bisphosphonates. Bone, 49, 34-41 (2011).
• 3) Pazianas M, Abrahamsen B. Safety of bisphosphonates. Bone, 49, 103-110 (2011).
• 4) Sedghizadeh PP, Stanley K, Caligiuri M, Hofkes S, Lowry B, Shuler CF. Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw. J. Am. Dent. Assoc., 140, 61-66 (2009).
• 5) Anastasilakis AD, Goulis DG, Kita M, Avramidis A. Oral bisphosphonate adverse effects in 849 patients with metabolic bone diseases. Hormones, 6, 233-241 (2007).

Terms in the title (11)： 酸 ,  リン酸トランスポーター ,  細胞 ,  窒素 ,  ビスホスホネート ,  流入 ,  阻害 ,  炎症 ,  壊死 ,  副作用 ,  マウス