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J-GLOBAL ID：201602231134178435   Reference number：16A1395445

Microglial phospholipase D4 deficiency influences myelination during brain development

ミクログリアのホスホリパーゼD4欠乏は脳成熟期の髄鞘形成に影響する

Author (9)： CHIBA Terumasa (Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences) ,  OTANI Yoshinori (Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences) ,  YAMAGUCHI Yoshihide (Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences) ,  ISHIBASHI Tomoko (Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences) ,  HAYASHI Akiko (Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences) ,  TANAKA Kenji F. (Department of Neuropsychiatry, School of Medicine, Keio University) ,  YAMAZAKI Maya (Department of Cellular Neurobiology, Brain Research Institute, Niigata University) ,  SAKIMURA Kenji (Department of Cellular Neurobiology, Brain Research Institute, Niigata University) ,  BABA Hiroko (Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences)
Material： Proceedings of the Japan Academy. Series B. Physical and Biological Sciences  (日本学士院紀要 B)
Volume： 92  Issue： 7  Page： 237-254(J-STAGE)  Publication year： 2016 
JST Material Number： G0485B  ISSN： 0386-2208  CODEN： PJABDW  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *microglia ,...
Semi thesaurus term： *knockdown ,...

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Author keywords (5)： phospholipase D ,  microglia ,  myelin ,  brain ,  development

JST classification (4)： Neurology in general  (GN01010L) ,  Enzyme in general  (EB09010D) ,  Gene manipulation  (EC02050B) ,  Nervous system in general  (EJ12010J)

Reference (42)：

• 1) Sato, A., Sekine, Y., Saruta, C., Nishibe, H., Morita, N., Sato, Y., Sadakata, T., Shinoda, Y., Kojima, T. and Furuichi, T. (2008) Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum. Neural Netw. 21, 1056-1069.
• 2) Yoshikawa, F., Banno, Y., Otani, Y., Yamaguchi, Y., Nagakura-Takagi, Y., Morita, N., Sato, Y., Saruta, C., Nishibe, H., Sadakata, T., Shinoda, Y., Hayashi, K., Mishima, Y., Baba, H. and Furuichi, T. (2010) Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia. PLoS One 5, e13932.
• 3) Frohman, M.A. (2015) The phospholipase D superfamily as therapeutic targets. Trends Pharmacol. Sci. 36, 137-144.
• 4) Terao, C., Ohmura, K., Kawaguchi, Y., Nishimoto, T., Kawasaki, A., Takehara, K., Furukawa, H., Kochi, Y., Ota, Y., Ikari, K., Sato, S., Tohma, S., Yamada, R., Yamamoto, K., Kubo, M., Yamanaka, H., Kuwana, M., Tsuchiya, N., Matsuda, F. and Mimori, T. (2013) PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population. Arthritis Rheum. 65, 472-480.
• 5) Jung, S., Pausch, H., Langenmayer, M.C., Schwarzenbacher, H., Majzoub-Altweck, M., Gollnick, N.S. and Fries, R. (2014) A nonsense mutation in PLD4 is associated with a zinc deficiency-like syndrome in Fleckvieh cattle. BMC Genomics 15, 623.

Terms in the title (5)： ミクログリア ,  欠乏 ,  脳 ,  成熟期 ,  髄鞘形成