Art

J-GLOBAL ID：201602233096134544   Reference number：16A0918201

Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells

ニメスリドの異性体ヨード化アナログ: 合成,物理化学的特性化,シクロオキシゲナーゼ-2阻害活性,及びCaco-2細胞への輸送

Author (8)： Yamamoto Yumi (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Arai Jun (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Hisa Takuya (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Saito Yohei (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Mukai Takahiro (Kobe Pharmaceutical University, 4-19-1 Motoyama Kitamachi, Higashinada-ku, Kobe 658-8558, Japan) ,  Ohshima Takashi (Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Maeda Minoru (Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan) ,  Yamamoto Fumihiko (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 24  Issue： 16  Page： 3727-3733  Publication year： Aug. 15, 2016 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *contrast media ,  drug design ,  enzyme inhibitor ,  *cyclooxygenase ,  *non-steroidal anti-inflammatory agent ,  molecular targeting drug ,  *iodination ,  Caco2 cell ,  drug absorption ,  in vitro experiment ,  *radiopharmaceutical ,  chemical synthesis ,  brain diagnosis ,  *vascular permeability ,  structure-activity relationship ,  P glycoprotein ,  aromatic amine ,  aromatic nitro compound ,  sulfonamide ,  phenol ether
Semi thesaurus term： COX-2 inhibitor ,  *COX2 ,  *radioiodination ,  drug synthesis ,  *blood-brain barrier permeability

Author keywords (6)： Nimesulide ,  COX-2 ,  Iodine ,  Caco-2 cell monolayers ,  Lipophilicity ,  Blood-brain barrier

JST classification (2)： Basic research of diagnostic drugs  (GW20010P) ,  Aromatic monocyclic amine,imine,quaternary ammonium,immonium compounds  (CF05050D)

Substance index (1)： Nimesulide

Terms in the title (8)： ニメスリド ,  異性体 ,  アナログ ,  物理化学的特性 ,  シクロオキシゲナーゼ-2 ,  阻害活性 ,  Caco-2細胞 ,  輸送