Art

J-GLOBAL ID：201602237966202917   Reference number：16A1395623

Preventive effect of sildenafil on right ventricular function in rats with monocrotaline-induced pulmonary arterial hypertension

モノクロタリン誘発肺動脈性肺高血圧症ラットの右心室機能に対するシルデナフィルの予防効果

Author (4)： Yoshiyuki Rieko (Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan) ,  Tanaka Ryo (Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan) ,  Fukushima Ryuji (Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan) ,  Machida Noboru (Department of Veterinary Clinical Oncology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan)
Material： Experimental Animals  (実験動物ニュース)
Volume： 65  Issue： 3  Page： 215-222(J-STAGE)  Publication year： 2016 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： *Ventricular Function, Right ,...

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Author keywords (4)： monocrotaline ,  pulmonary hypertension ,  rat ,  sildenafil

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of cardioactive drugs  (GW07020N)

Substance index (2)： Sildenafil ,  Monocrotaline

Reference (37)：

• 1. Blanchard D.G., Malouf P.J., Gurudevan S.V., Auger W.R., Madani M.M., Thistlethwaite P., Waltman T.J., Daniels L.B., Raisinghani A.B., and DeMaria A.N. 2009. Utility of right ventricular Tei index in the noninvasive evaluation of chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy. JACC Cardiovasc. Imaging 2: 143-149.
• 2. Borgdorff M.A., Bartelds B., Dickinson M.G., van Wiechen M.P., Steendijk P., de Vroomen M., and Berger R.M. 2014. Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload. Am. J. Physiol. Heart Circ. Physiol. 307: H361-H369.
• 3. Buyukakilli B., Gurgul S., Citirik D., Hallioglu O., Ozeren M., and Tasdelen B. 2014. Determination of the effects of pulmonary arterial hypertension and therapy on the cardiovascular system of rats by impedance cardiography. Croat. Med. J. 55: 498-506.
• 4. Carlino C., Tobias J.D., Schneider R.I., Heller R.L., Alpert M.A., Grueber R.E., Dellsperger K.C., and Demarco V.G. 2010. Pulmonary hemodynamic response to acute combination and monotherapy with sildenafil and brain natriuretic peptide in rats with monocrotaline-induced pulmonary hypertension. Am. J. Med. Sci. 339: 55-59.
• 5. Condliffe R., Kiely D.G., Peacock A.J., Corris P.A., Gibbs J.S., Vrapi F., Das C., Elliot C.A., Johnson M., DeSoyza J., Torpy C., Goldsmith K., Hodgkins D., Hughes R.J., Pepke-Zaba J., and Coghlan J.G. 2009. Connective tissue disease-associated pulmonary arterial hypertension in the modern treatment era. Am. J. Respir. Crit. Care Med. 179: 151-157.

Terms in the title (7)： モノクロタリン ,  誘発 ,  肺動脈性肺高血圧症 ,  ラット ,  右心室機能 ,  シルデナフィル ,  予防効果