Art

J-GLOBAL ID：201602246114258004   Reference number：16A1175843

Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging

LAT1による3-フルオロ-l-α-メチル-チロシンの特異的輸送は,画像診断で悪性腫瘍に対するその特異性を説明する

Author (10)： Wei Ling (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Tominaga Hideyuki (Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan) ,  Ohgaki Ryuichi (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Wiriyasermkul Pattama (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Hagiwara Kohei (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Okuda Suguru (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Kaira Kyoichi (Department of Oncology Clinical Development, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Oriuchi Noboru (Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan) ,  Nagamori Shushi (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Kanai Yoshikatsu (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 107  Issue： 3  Page： 347-352  Publication year： 2016 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Membrane Proteins ,...
Semi thesaurus term： *FAMT-PET ,...

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Author keywords (5)： Amino acid transporter ,  biomarker ,  molecular probe ,  PET ,  tumor imaging

JST classification (3)： Basic oncology in general  (GE02010R) ,  Transport of cell membrane  (EF04020R) ,  Tumors(=neoplasms)of female genitalia and fetus  (GS04000K)

Substance index (2)： FAMT ,  Methionine

Reference (34)：

• Plathow C, Weber WA. Tumor cell metabolism imaging. J Nucl Med 2008; 49(Suppl 2): 43S-63S.
• Cook GJ, Maisey MN, Fogelman I. Normal variants, artefacts and interpretative pitfalls in PET imaging with 18-fluoro-2-deoxyglucose and carbon-11 methionine. Eur J Nucl Med 1999; 26: 1363-78.
• Jager PL, Vaalburg W, Pruim J, de Vries EG, Langen KJ, Piers DA. Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med 2001; 42: 432-45.
• Deloar HM, Fujiwara T, Nakamura T et al. Estimation of internal absorbed dose of l-[methyl-¹¹C]methionine using whole-body positron emission tomography. Eur J Nucl Med 1998; 25: 629-33.
• Pauleit D, Floeth F, Herzog H et al. Whole-body distribution and dosimetry of O-(2-¹⁸F-fluoroethyl)-l-tyrosine. Eur J Nucl Med Mol Imaging 2003; 30: 519-24.

Terms in the title (7)： LAT1 ,  チロシン ,  輸送 ,  画像診断 ,  悪性腫瘍 ,  特異性 ,  説明