Art

J-GLOBAL ID：201602248432448811   Reference number：16A1100476

Toward the treatment for Alzheimer’s disease: adsorption is primary mechanism of removing amyloid β protein with hollow-fiber dialyzers of the suitable materials, polysulfone and polymethyl methacrylate

アルツハイマー病の治療に向けて:吸着は,適切な材料,ポリスルホンやポリメタクリ酸メチルの中空繊維透析器によるアミロイドβ蛋白質を除去するための主要な機序である

Author (9)： Kawaguchi Kazunori (Faculty of Clinical Engineering, School of Health Science, Fujita Health University, Toyoake, Aichi, Japan) ,  Saigusa Akira (Juntendo University Hospital, Bunkyo, Japan) ,  Yamada Shinji (Chukyo Hospital, Nagoya, Japan) ,  Gotoh Takehiro (Mie University Hospital, Tsu, Japan) ,  Nakai Shigeru (Faculty of Clinical Engineering, School of Health Science, Fujita Health University, Toyoake, Aichi, Japan) ,  Hiki Yoshiyuki (Faculty of Clinical Engineering, School of Health Science, Fujita Health University, Toyoake, Aichi, Japan) ,  Hasegawa Midori (Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Japan) ,  Yuzawa Yukio (Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Japan) ,  Kitaguchi Nobuya (Faculty of Clinical Engineering, School of Health Science, Fujita Health University, Toyoake, Aichi, Japan)
Material： Journal of Artificial Organs  (J Artif Organs)
Volume： 19  Issue： 2  Page： 149-158  Publication year： 2016 
JST Material Number： L3970A  ISSN： 1434-7229  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： Alzheimer disease ,...
Semi thesaurus term： *A beta 1-42 ,...

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Author keywords (4)： Alzheimer’s disease ,  Amyloid-β (Aβ) ,  Apheresis ,  Hemodialysis

JST classification (2)： Medical instruments and apparatuses  (GA05020L) ,  Basic neurology  (GN01020W)

Reference (13)：

• Selkoe DJ. Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev. 2001;81:741-66.
• Hung LW, Ciccotosto GD, Giannakis E, Tew DJ, Perez K, Masters CL, Cappai R, Wade JD, Barnham KJ. Amyloid-β peptide (Aβ) neurotoxicity is modulated by the rate of peptide aggregation: Aβ dimers and trimers correlate with neurotoxicity. J Neurosci. 2008;28:11950-8.
• Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid b protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 2002;416:535-9.
• Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ. Decreased clearance of CNS β-amyloid in Alzheimer’s disease. Science. 2010;330:1774.
• Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. Transport pathways for clearance of human Alzheimer’s amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2007;27:909-18.

Terms in the title (8)： アルツハイマー ,  治療 ,  吸着 ,  ポリスルホン ,  メタクリ酸メチル ,  中空繊維 ,  透析器 ,  アミロイドβ蛋白質