Art

J-GLOBAL ID：201602261414959109   Reference number：16A0917132

Cryptic antifungal compounds active by synergism with polyene antibiotics

ポリエン系抗生物質との相乗作用により活性となる潜在的抗真菌薬

Author (5)： Kinoshita Hiroshi (International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Yoshioka Mariko (International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ihara Fumio (National Institute of Fruit Tree Science, 2-1 Fujimoto, Tsukuba, Ibaraki 305-8605, Japan) ,  Nihira Takuya (International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Nihira Takuya (MU-OU Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Rama VI Rd., Bangkok 10400, Thailand)
Material： Journal of Bioscience and Bioengineering
Volume： 121  Issue： 4  Page： 394-398  Publication year： Apr. 2016 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *antifungal drug ,...
Semi thesaurus term： Eumycetes ,...

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Author keywords (5)： Key words Antifungal compounds ,  Polyene antibiotics ,  Helvolic acid ,  Terramide A ,  Entomopathogenic fungi

JST classification (2)： Microorganism biochemistry  (EG03020N) ,  Microorganism physiology in general  (EG03051L)

Substance index (4)： Terramide A ,  Ergosterol ,  Nystatin ,  Helvolic acid

Reference (24)：

• Aparicio, J. F, Caffrey, P., Gil, J. A., and Zotchev, S. B.: Polyene antibiotic biosynthesis gene clusters, Appl. Microbiol. Biotechnol., 61, 179-188 (2003).
• Zotchev, S. B.: Polyene macrolide antibiotics and their applications in human therapy, Curr. Med. Chem., 10, 211-223 (2003).
• Bolard, J.: How do the polyene macrolide antibiotics affect the cellular membrane properties? Biochim. Biophys. Acta, 864, 257-304 (1986).
• Finkelstein, A. and Holz, R.: Aqueous pores created in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B, Membranes, 2, 377-408 (1973).
• Marty, A. and Finkelstein, A.: Pores formed in lipid bilayer membranes by nystatin, differences in its one-sided and two-sided action, J. Gen. Physiol., 65, 515-526 (1975).

Terms in the title (4)： ポリエン系抗生物質 ,  相乗作用 ,  活性 ,  抗真菌薬