Art

J-GLOBAL ID：201602261531938660   Reference number：16A1067702

Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7α-[¹⁸F]fluoro- and 10-O-p-[¹¹C]methylbenzyl ginkgolide B in monkey and rat brains

ギンコライドの血液脳関門透過性:サルおよびラットの脳におけるPETプローブ7a-[¹⁸F]フルオロ-および10-O-p-[¹¹C]メチルベンジルギンコリドBの挙動の比較

Author (11)： Doi Hisashi (Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan) ,  Sato Kengo (PET Medical Application Group, Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita-ku, Hamamatsu 434-8601, Japan) ,  Shindou Hideo (Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan) ,  Sumi Kengo (Division of Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan) ,  Koyama Hiroko (Division of Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan) ,  Hosoya Takamitsu (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Watanabe Yasuyoshi (Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan) ,  Ishii Satoshi (Department of Immunology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan) ,  Tsukada Hideo (PET Center, Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita-ku, Hamamatsu 434-8601, Japan) ,  Nakanishi Koji (Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA) ,  Suzuki Masaaki (Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 24  Issue： 21  Page： 5148-5157  Publication year： Nov. 01, 2016 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *diterpene ,  vascular permeability ,  *blood-brain barrier ,  probe ,  chemical synthesis ,  PET(tomography) ,  rat ,  Macaca mulatta ,  bioaccumulation ,  lactone ,  bridged compound ,  polyol
Semi thesaurus term： *Ginkgolides ,  blood-brain barrier permeability ,  PET probe

Author keywords (5)： Ginkgolide B ,  Platelet-activating factor ,  Blood-brain barrier ,  PET ,  C-[¹¹C]methylation

JST classification (1)： Diterpenes,sesterterpenes  (CF10023R)

Substance index (1)： Ginkgolide B

Terms in the title (7)： ギンコライド ,  血液脳関門透過性 ,  サル ,  ラット ,  脳 ,  PETプローブ ,  挙動