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J-GLOBAL ID：201602261896920248   Reference number：16A1175726

Antidepressive-like effect of volatile components of kososan in a mouse model of stress-induced depression

ストレス誘発欝病のマウスモデルにおける香蘇散の揮発性成分の抗欝様効果

Author (13)： Ito Naoki (Oriental Medicine Research Center, Kitasato University, Tokyo, Japan. [e-mail]) ,  Nagai Takayuki (Oriental Medicine Research Center, Kitasato University, Tokyo, Japan) ,  Nagai Takayuki (Laboratory of Biochemical Pharmacology for Phytomedicines, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan) ,  Nagai Takayuki (Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan) ,  Hirose Eiji (Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan) ,  Kiyohara Hiroaki (Oriental Medicine Research Center, Kitasato University, Tokyo, Japan) ,  Kiyohara Hiroaki (Laboratory of Biochemical Pharmacology for Phytomedicines, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan) ,  Kiyohara Hiroaki (Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan) ,  Oikawa Tetsuro (Oriental Medicine Research Center, Kitasato University, Tokyo, Japan) ,  Yamada Haruki (Oriental Medicine Research Center, Kitasato University, Tokyo, Japan) ,  Yamada Haruki (Laboratory of Biochemical Pharmacology for Phytomedicines, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan) ,  Yamada Haruki (Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan) ,  Hanawa Toshihiko (Oriental Medicine Research Center, Kitasato University, Tokyo, Japan)
Material： Traditional & Kampo Medicine  (Tradit Kampo Med)
Volume： 3  Issue： 2  Page： 87-93  Publication year： Oct. 2016 
JST Material Number： Y0941B  ISSN： 2053-4515  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Chinese drug ,...
Semi thesaurus term： *Koso-san

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Author keywords (6)： antidepressive-like activity ,  depression ,  kampo medicine ,  kososan ,  perillaldehyde ,  volatile component

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of psychotropic drugs  (GW03100Y)

Substance index (1)： Perillaldehyde

Reference (18)：

• Hanawa T. Kososan and hangekobokuto. J. Kampo Med. 1995; 42: 418-426.
• Ito N, Nagai T, Yabe T, Nunome S, Hanawa T, Yamada H. Antidepressant-like activity of a kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis. Phytomedicine 2006; 13: 658-667.
• Nagai T, Narikawa T, Ito N, Takeda T, Hanawa T, Yamada H. Antidepressant-like effect of a kampo (Japanese herbal) medicine, kososan, against the interferon-α-induced depressive-like model mice. J. Trad. Med. 2008; 25: 74-80.
• Ito N, Yabe T, Nagai T, Oikawa T, Yamada H, Hanawa T. A possible mechanism underlying an antidepressive-like effect of Kososan, a kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice. Biol. Pharm. Bull. 2009; 32:1716-1722.
• Ito N, Hori A, Yabe T et al. Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a kampo medicine, in the stress-induced depression-like model mice. Biol. Pharm. Bull. 2012; 35:1775-1783.

Terms in the title (7)： ストレス ,  誘発 ,  欝病 ,  マウスモデル ,  香蘇散 ,  揮発性成分 ,  欝