Art

J-GLOBAL ID：201602285295803835   Reference number：16A1391912

Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome - First-in-Human Pilot Study -

ポスト心停止症候群に対する水素ガス吸入の実現可能性と安全性 - ヒトにおける最初のパイロット研究 -

Author (16)： Tamura Tomoyoshi (Department of Emergency and Critical Care Medicine, Keio University School of Medicine) ,  Tamura Tomoyoshi (The Center for Molecular Hydrogen Medicine, Keio University) ,  Hayashida Kei (Department of Emergency and Critical Care Medicine, Keio University School of Medicine) ,  Hayashida Kei (The Center for Molecular Hydrogen Medicine, Keio University) ,  Sano Motoaki (The Center for Molecular Hydrogen Medicine, Keio University) ,  Sano Motoaki (Department of Cardiology, Keio University School of Medicine) ,  Suzuki Masaru (Department of Emergency and Critical Care Medicine, Keio University School of Medicine) ,  Suzuki Masaru (The Center for Molecular Hydrogen Medicine, Keio University) ,  Shibusawa Takayuki (Department of Emergency and Critical Care Medicine, Keio University School of Medicine) ,  Yoshizawa Joe (Department of Emergency and Critical Care Medicine, Keio University School of Medicine) ,  Kobayashi Yosuke (Department of Emergency and Critical Care Medicine, Keio University School of Medicine) ,  Suzuki Takeshi (Department of Anesthesiology, Keio University School of Medicine) ,  Ohta Shigeo (Department of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School) ,  Morisaki Hiroshi (Department of Anesthesiology, Keio University School of Medicine) ,  Fukuda Keiichi (Department of Cardiology, Keio University School of Medicine) ,  Hori Shingo (Department of Emergency and Critical Care Medicine, Keio University School of Medicine)
Material： Circulation Journal  (Circ J)
Volume： 80  Issue： 8  Page： 1870-1873(J-STAGE)  Publication year： 2016 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Heart Arrest ,...
Semi thesaurus term： cardiac function ,...

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Author keywords (4)： Hydrogen gas inhalation ,  Molecular hydrogen ,  Post-cardiac arrest syndrome ,  Return of spontaneous circulation

JST classification (2)： Treatment for cardiovasular system diseases in general  (GJ05010B) ,  Epidemiology  (GB03000E)

Reference (5)：

• 1. Soga T, Nagao K, Sawano H, Yokoyama H, Tahara Y, Hase M, et al. Neurological benefit of therapeutic hypothermia following return of spontaneous circulation for out-of-hospital non-shockable cardiac arrest. Circ J 2012; 76: 2579-2585.
• 2. Merchant RM, Soar J, Skrifvars MB, Silfvast T, Edelson DP, Ahmad F, et al. Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest. Crit Care Med 2006; 34: 1935-1940.
• 3. Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, et al. H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc 2012; 1: e003459, doi:10.1161/JAHA.112.003459.
• 4. Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, et al. Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management. Circulation 2014; 130: 2173-2180.
• 5. Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Bottiger BW, et al. Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008; 118: 2452-2483.

Terms in the title (9)： 心停止 ,  症候群 ,  水素ガス ,  吸入 ,  実現可能性 ,  安全性 ,  ヒト ,  パイロット ,  研究