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J-GLOBAL ID：201602285666653189   Reference number：16A1227404

In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor

強力なD-アミノ酸オキシダーゼ阻害剤の同定のためのin situクリックケミストリー

Author (9)： Toguchi Shohei (Graduate School of Infection Control Sciences, Kitasato University) ,  Hirose Tomoyasu (Graduate School of Infection Control Sciences, Kitasato University) ,  Hirose Tomoyasu (The Kitasato Institute for Life Sciences, Kitasato University) ,  Yorita Kazuko (Institute for Enzyme Research, Tokushima University) ,  Fukui Kiyoshi (Institute for Enzyme Research, Tokushima University) ,  Sharpless K. Barry (Department of Chemistry, The Scripps Research Institute) ,  Omura Satoshi (The Kitasato Institute for Life Sciences, Kitasato University) ,  Sunazuka Toshiaki (Graduate School of Infection Control Sciences, Kitasato University) ,  Sunazuka Toshiaki (The Kitasato Institute for Life Sciences, Kitasato University)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 64  Issue： 7  Page： 695-703(J-STAGE)  Publication year： 2016 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *D-amino-acid oxidase ,...
Semi thesaurus term： IC50 ,...

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Author keywords (12)： fragment-based lead discovery ,  templated reaction ,  ligand-binding site ,  drug discovery ,  triazole formation ,  ligand affinity ,  fragment-based lead discovery ,  templated reaction ,  ligand-binding site ,  drug discovery ,  triazole formation ,  ligand affinity

JST classification (1)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Reference (46)：

• 1) Park H. K., Shishido Y., Ichise-Shishido S., Kawazoe T., Ono K., Iwana S., Tomita Y., Yorita K., Sakai T., Fukui K., J. Biochem., 139, 295-304 (2006).
• 2) Krebs H. A., Biochem. J., 29, 1620-1644 (1935).
• 3) Javitt D. C., Zukin S. R., Am. J. Psychiatry, 148, 1301-1308 (1991).
• 4) Krystal J. H., Karper L. P., Seibyl J. P., Freeman G. K., Delaney R., Bremner J. D., Heninger G. R., Bowers M. B. Jr., Charney D. S., Arch. Gen. Psychiatry, 51, 199-214 (1994).
• 5) Chumakov I., Blumenfeld M., Guerassimenko O., Cavarec L., Palicio M., Abderrahim H., Bougueleret L., Barry C., Tanaka H., La Rosa P., Puech A., Tahri N., Cohen-Akenine A., Delabrosse S., Lissarrague S., Picard F.-P., Maurice K., Essioux L., Millasseau P., Grel P., Debailleul V., Simon A.-M., Caterina D., Dufaure I., Malekzadeh K., Belova M., Luan J.-J., Bouillot M., Sambucy J.-L., Primas G., Saumier M., Boubkiri N., Martin-Saumier S., Nasroune M., Peixoto H., Delaye A., Pinchot V., Bastucci M., Guillou S., Chevillon M., Sainz-Fuertes R., Meguenni S., Aurich-Costa J., Cherif D., Gimalac A., Van Duijn C., Gauvreau D., Ouellette G., Fortier I., Raelson J., Sherbatich T., Riazanskaia N., Rogaev E., Raeymaekers P., Aerssens J., Konings F., Luyten W., Macciardi F., Sham P. C., Straub R. E., Weinberger D. R., Cohen N., Cohen D., Proc. Natl. Acad. Sci. U.S.A., 99, 13675-13680 (2002).

Terms in the title (4)： D-アミノ酸オキシダーゼ ,  阻害剤 ,  同定 ,  クリックケミストリー