Art

J-GLOBAL ID：201602285666653189   Reference number：16A1227404

In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor

強力なD-アミノ酸オキシダーゼ阻害剤の同定のためのin situクリックケミストリー

Author (9)： Toguchi Shohei (Graduate School of Infection Control Sciences, Kitasato University) ,  Hirose Tomoyasu (Graduate School of Infection Control Sciences, Kitasato University) ,  Hirose Tomoyasu (The Kitasato Institute for Life Sciences, Kitasato University) ,  Yorita Kazuko (Institute for Enzyme Research, Tokushima University) ,  Fukui Kiyoshi (Institute for Enzyme Research, Tokushima University) ,  Sharpless K. Barry (Department of Chemistry, The Scripps Research Institute) ,  Omura Satoshi (The Kitasato Institute for Life Sciences, Kitasato University) ,  Sunazuka Toshiaki (Graduate School of Infection Control Sciences, Kitasato University) ,  Sunazuka Toshiaki (The Kitasato Institute for Life Sciences, Kitasato University)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 64  Issue： 7  Page： 695-703(J-STAGE)  Publication year： 2016 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *D-Amino-Acid Oxidase ,...
Semi thesaurus term： IC50 ,...

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Author keywords (12)： fragment-based lead discovery ,  templated reaction ,  ligand-binding site ,  drug discovery ,  triazole formation ,  ligand affinity ,  fragment-based lead discovery ,  templated reaction ,  ligand-binding site ,  drug discovery ,  triazole formation ,  ligand affinity

JST classification (1)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Reference (46)：

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Terms in the title (4)： D-アミノ酸オキシダーゼ ,  阻害剤 ,  同定 ,  クリックケミストリー