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J-GLOBAL ID：201702212363012985   Reference number：17A1435937

Notable Drug-Drug Interaction Between Etizolam and Itraconazole in Poor Metabolizers of Cytochrome P450 2C19

チトクロームP4502C19のプアーメタボライザーにおけるEtizolamおよびイトラコナゾールの注目される薬物-薬物相互作用【Powered by NICT】

Author (13)： Yamamoto Takehito (Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan) ,  Furihata Kenichi (P-One Clinic, Keikokai Medical Corporation, Tokyo, Japan) ,  Furihata Kenichi (Department of Clinical Pharmacology, Tokai University School of Medicine, Kanagawa, Japan) ,  Hisaka Akihiro (Pharmacology and Pharmacokinetics, The University of Tokyo Hospital) ,  Hisaka Akihiro (Present affiliation: Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan) ,  Moritoyo Takashi (Department of Clinical Research Governance, The University of Tokyo Hospital, Tokyo, Japan) ,  Ogoe Kazuaki (P-One Clinic, Keikokai Medical Corporation, Tokyo, Japan) ,  Kusayama Shizuko (P-One Clinic, Keikokai Medical Corporation, Tokyo, Japan) ,  Motohashi Keiju (Unit for Early and Exploratory Clinical Department, The University of Tokyo Hospital, Tokyo, Japan) ,  Mori Akiko (Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan) ,  Iwatsubo Takeshi (Unit for Early and Exploratory Clinical Department, The University of Tokyo Hospital, Tokyo, Japan) ,  Iwatsubo Takeshi (Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Suzuki Hiroshi (Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan)
Material： Journal of Clinical Pharmacology  (J Clin Pharmacol)
Volume： 57  Issue： 11  Page： 1491-1499  Publication year： 2017 
JST Material Number： B0350B  ISSN： 0091-2700  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： In this study, impact of a pol...

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Thesaurus term： pharmacokinetics ,  *cytochrome P450 ,  plasma concentration ,  Metabolism ,  *drug interaction ,  area under the blood concentration time curve ,  substrate (biochemistry) ,  in vitro experiment ,  oral administration ,  Microsomes, Liver ,  coadministration ,  CYP3A ,  Cytochrome P450 2C19 ,  nitrogen heterocyclic compound ,  aromatic chlorine compound ,  sulfur heterocyclic compound ,  oxygen heterocyclic compound ,  urea compound ,  phenol ether

Author keywords (5)： pharmacogenetics/pharmacogenomics ,  drug-drug interaction ,  polymorphisms ,  cytochrome P450 ,  poor metabolizer

JST classification (2)： Interactions of drugs  (GV01070X) ,  Clinical biopharmacy  (GY01022L)

Substance index (2)： Etizolam ,  Itraconazol

Terms in the title (4)： イトラコナゾール ,  注目 ,  薬物 ,  薬物相互作用