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J-GLOBAL ID：201702212573563840   Reference number：17A1175684

Diabetic phenotype of transgenic pigs introduced by dominant-negative mutant hepatocyte nuclear factor 1α

ドミナントネガティブ変異体の肝細胞核因子1αにより導入されたトランスジェニックブタの糖尿病表現型【Powered by NICT】

Author (7)： Umeyama Kazuhiro (Meiji University International Institute for Bio-Resource Research, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan) ,  Umeyama Kazuhiro (Laboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan) ,  Nakajima Masami (Department of Ophthalmology, Nihon University School of Medicine, 30-1 Oyaguchi, Kamicho, Itabashi-ku, Tokyo 173-8610, Japan) ,  Yokoo Takashi (Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan) ,  Nagaya Masaki (Meiji University International Institute for Bio-Resource Research, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan) ,  Nagashima Hiroshi (Meiji University International Institute for Bio-Resource Research, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan) ,  Nagashima Hiroshi (Laboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan)
Material： Journal of Diabetes and Its Complications
Volume： 31  Issue： 5  Page： 796-803  Publication year： 2017 
JST Material Number： W3214A  ISSN： 1056-8727  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The present study aimed to ide...

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Thesaurus term： man ,  *diabetes mellitus ,  blood glucose ,  gene ,  pathology ,  *phenotype ,  diabetic retinopathy ,  hyperglycemia ,  *variation(biology) ,  Langerhans islet ,  human(primates) ,  diabetic nephropathy
Semi thesaurus term： 病理組織像 ,  遺伝子組換 ,  *トランスジェニックブタ , 【Automatic Indexing@JST】

Author keywords (6)： Transgenic pig ,  HNF1α (hepatocyte nuclear factor 1α) ,  Dominant-negative mutant ,  MODY3 (maturity-onset diabetes of the young type 3) ,  Diabetic retinopathy ,  Diabetic nephropathy

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Gene expression  (EC02040Q) ,  Molecular genetics in general  (EC02010J)

Terms in the title (5)： ドミナントネガティブ変異体 ,  肝細胞核因子1α ,  トランスジェニックブタ ,  糖尿病 ,  表現型