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J-GLOBAL ID：201702212836949891   Reference number：17A1973518

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

調節性T細胞のSlc3a2を仲介する分枝鎖アミノ酸依存的維持【Powered by NICT】

Author (33)： Ikeda Kayo (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Ikeda Kayo (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Ikeda Kayo (Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Kinoshita Makoto (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Kinoshita Makoto (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Kayama Hisako (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Kayama Hisako (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Nagamori Shushi (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Nagamori Shushi (Laboratory of Biomolecular Dynamics, Department of Collaborative Research, Nara Medical University, Nara, Japan) ,  Kongpracha Pornparn (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Kongpracha Pornparn (Laboratory of Biomolecular Dynamics, Department of Collaborative Research, Nara Medical University, Nara, Japan) ,  Umemoto Eiji (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Umemoto Eiji (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Okumura Ryu (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Okumura Ryu (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Kurakawa Takashi (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Kurakawa Takashi (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Murakami Mari (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Murakami Mari (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Murakami Mari (Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Mikami Norihisa (Department of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Shintani Yasunori (Department of Medical Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Ueno Satoko (Fundamental Technology Laboratory, Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Japan) ,  Andou Ayatoshi (Innovation Promotion Department, Research Institute, EA Pharma Co., Ltd., Kawasaki, Japan) ,  Ito Morihiro (Department of Microbiology, College of Life and Health Science, Chubu University, Aichi, Japan) ,  Tsumura Hideki (Division of Animal Resources, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Yasutomo Koji (Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan) ,  Ozono Keiichi (Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Takashima Seiji (Department of Medical Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan) ,  Sakaguchi Shimon (Department of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Kanai Yoshikatsu (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Takeda Kiyoshi (Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan) ,  Takeda Kiyoshi (Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan)
Material： Cell Reports
Volume： 21  Issue： 7  Page： 1824-1838  Publication year： 2017 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Foxp3⁺ regulatory T...

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Thesaurus term： Viscera ,  *branched-chain amino acid ,  duplicate ,  Inflammation ,  *regulatory T cell ,  Cell Count ,  metabolic regulation ,  Metabolism ,  mTORC1 ,  Cell damage ,  reprogramming ,  immune response ,  Amino Acid Transport Systems ,  aliphatic amine ,  aliphatic carboxylic acid ,  primary amine
Semi thesaurus term： immunological reaction ,  増殖能 ,  アミノ酸輸送体 , 【Automatic Indexing@JST】

Author keywords (5)： Treg cells ,  amino acids ,  immunometabolism ,  immune regulation ,  transporter

JST classification (1)： Immunological reaction in general  (ED03010T)

Substance index (1)： Isoleucine

Terms in the title (4)： 調節性T細胞 ,  SLC3A2 ,  仲介 ,  分枝鎖アミノ酸