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J-GLOBAL ID：201702215408560723   Reference number：17A0907360

Identification of a trichothecene production inhibitor by chemical array and library screening using trichodiene synthase as a target protein

標的蛋白質としてのトリコジエンシンターゼを用いた化学アレイとライブラリースクリーニングによるトリコテセン産生阻害剤の同定【Powered by NICT】

Author (14)： Maeda Kazuyuki (Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan) ,  Maeda Kazuyuki (Graduate School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan) ,  Nakajima Yuichi (Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan) ,  Nakajima Yuichi (Chemical Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Motoyama Takayuki (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Kondoh Yasumitsu (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Kawamura Tatsuro (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Kanamaru Kyoko (Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan) ,  Ohsato Shuichi (Graduate School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan) ,  Nishiuchi Takumi (Division of Functional Genomics, Advanced Science Research Centre, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-0934, Japan) ,  Yoshida Minoru (Chemical Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Osada Hiroyuki (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Kobayashi Tetsuo (Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan) ,  Kimura Makoto (Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan)
Material： Pesticide Biochemistry and Physiology  (Pesticide Biochemistry & Physiology)
Volume： 138  Page： 1-7  Publication year： 2017 
JST Material Number： C0793A  ISSN： 0048-3575  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Trichothecene mycotoxins often...

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Thesaurus term： *synthase ,  enzyme inhibition ,  natural material ,  amino acid residue ,  pesticide ,  analogical material ,  cereal ,  Fusarium ,  alicyclic compound ,  oxygen heterocyclic compound ,  bridged compound ,  tricyclic sesquiterpene
Semi thesaurus term： アミド結合 ,  Fusarium graminearum ,  液体培養 ,  化合物ライブラリー ,  *阻害剤 ,  *標的蛋白質 , 【Automatic Indexing@JST】

Author keywords (6)： Chemical array ,  Fusarium graminearum ,  Gonane skeleton ,  Mixed-type inhibition ,  Trichodiene synthase ,  Trichothecene production inhibitor

JST classification (1)： Pesticides to weeds  (FB06030F)

Substance index (1)： Trichothecene

Terms in the title (8)： 標的蛋白質 ,  化学 ,  アレイ ,  ライブラリー ,  スクリーニング ,  トリコテセン ,  阻害剤 ,  同定