Art

J-GLOBAL ID：201702217161291481   Reference number：17A0127273

Comparison of preventive effect of sildenafil and therapeutic effect of sildenafil treatment in rats with monocrotaline-induced pulmonary arterial hypertension

モノクロタリン誘発肺動脈性肺高血圧があるラットにおけるシルデナフィルの予防効果およびシルデナフィル処置の治療効果の比較

Author (4)： YOSHIYUKI Rieko (Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan) ,  FUKUSHIMA Ryuji (Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan) ,  TANAKA Ryo (Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan) ,  MACHIDA Noboru (Department of Veterinary Clinical Oncology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan)
Material： Journal of Veterinary Medical Science  (日本獣医学会会誌)
Volume： 78  Issue： 10  Page： 1607-1610(J-STAGE)  Publication year： 2016 
JST Material Number： F0905A  ISSN： 0916-7250  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *pulmonary hypertension ,...
Semi thesaurus term： pulmonary arterial hypertension ,...

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Author keywords (5)： echocardiography ,  monocrotaline ,  pulmonary hypertension ,  rat ,  sildenafil

JST classification (1)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (2)： Monocrotaline ,  Sildenafil

Reference (29)：

• 1. Abe, K., Shimokawa, H., Morikawa, K., Uwatoku, T., Oi, K., Matsumoto, Y., Hattori, T., Nakashima, Y., Kaibuchi, K., Sueishi, K. and Takeshit, A. 2004. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ. Res. 94: 385-393.
• 2. Andersen, A., Nielsen, J. M., Rasalingam, S., Sloth, E. and Nielsen-Kudsk, J. E. 2013. Acute effects of sildenafil and dobutamine in the hypertrophic and failing right heart in vivo. Pulm. Circ. 3: 599-610.
• 3. Behzadnia, N., Najafizadeh, K., Sharif-Kashani, B., Dameshghi, D. O. and Shahabi, P. 2010. Noninvasive assessment of acute cardiopulmonary effects of an oral single dose of sildenafil in patients with idiopathic pulmonary hypertension. Heart Vessels 25: 313-318.
• 4. Campian, M. E., Hardziyenka, M., de Bruin, K., van Eck-Smit, B. L., de Bakker, J. M., Verberne, H. J. and Tan, H. L. 2010. Early inflammatory response during the development of right ventricular heart failure in a rat model. Eur. J. Heart Fail. 12: 653-658.
• 5. Cheitlin, M. D., Hutter, A. M. Jr., Brindis, R. G., Ganz, P., Kaul, S., Russell, R. O. Jr., Zusman, R. M., Technology and Practice Executive Committee. 1999. Use of sildenafil (Viagra) in patients with cardiovascular disease. Circulation 99: 168-177.

Terms in the title (8)： モノクロタリン ,  誘発 ,  肺動脈性肺高血圧 ,  ラット ,  シルデナフィル ,  予防効果 ,  処置 ,  治療効果