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J-GLOBAL ID：201702219431095082   Reference number：17A0814167

Pyruvate dehydrogenase complex regulator (PdhR) gene deletion boosts glucose metabolism in Escherichia coli under oxygen-limited culture conditions

ピルビン酸デヒドロゲナーゼ複合体レギュレータ(PdhR)遺伝子欠失は酸素制限培養条件下における大腸菌中でグルコース代謝を促進する

Author (9)： Maeda Soya (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan) ,  Shimizu Kumiko (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan) ,  Kihira Chie (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan) ,  Iwabu Yuki (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan) ,  Kato Ryuichi (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan) ,  Sugimoto Makoto (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan) ,  Fukiya Satoru (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan) ,  Wada Masaru (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan) ,  Yokota Atsushi (Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University, Kita-9 Nishi-9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan)
Material： Journal of Bioscience and Bioengineering
Volume： 123  Issue： 4  Page： 437-443  Publication year： Apr. 2017 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： gene ,...
Semi thesaurus term： cell physiology ,...

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Author keywords (6)： Key words PdhR ,  Pyruvate dehydrogenase complex ,  NADH dehydrogenase-2 ,  NAD⁺/NADH ratio ,  Acetic acid ,  Redox balance

JST classification (2)： Metabolism and nutrition  (EG03054K) ,  Molecular genetics in general  (EC02010J)

Substance index (2)： Pyruvic Acid ,  Acetic acid

Reference (16)：

• Noda, S., Takezawa, Y., Mizutani, T., Asakura, T., Nishiumi, E., Onoe, K., Wada, M., Tomita, F., Matsushita, K., and Yokota, A.: Alterations of cellular physiology in Escherichia coli in response to oxidative phosphorylation impaired by defective F₁-ATPase, J. Bacteriol., 188, 6869-6876 (2006).
• Sekine, H., Shimada, T., Hayashi, C., Ishiguro, A., Tomita, F., and Yokota, A.: H⁺-ATPase defect in Corynebacterium glutamicum abolishes glutamic acid production with enhancement of glucose consumption rate, Appl. Microbiol. Biotechnol., 57, 534-540 (2001).
• Yokota, A., Terasawa, Y., Takaoka, N., Shimizu, H., and Tomita, F.: Pyruvic acid production by an F₁-ATPase-defective mutant of Escherichia coli W1485lip2, Biosci. Biotechnol. Biochem., 58, 2164-2167 (1994).
• Yokota, A., Henmi, M., Takaoka, N., Hayashi, C., Takezawa, Y., Fukumori, Y., and Tomita, F.: Enhancement of glucose metabolism in a pyruvic acid-hyperproducing Escherichia coli mutant defective in F₁-ATPase activity, J. Ferment. Bioeng., 83, 132-138 (1997).
• Wada, M., Narita, K., and Yokota, A.: Alanine production in an H⁺-ATPase- and lactate dehydrogenase-defective mutant of Escherichia coli expressing alanine dehydrogenase, Appl. Microbiol. Biotechnol., 76, 819-825 (2007).

Terms in the title (9)： ピルビン酸デヒドロゲナーゼ複合体 ,  レギュレータ ,  遺伝子欠失 ,  酸素 ,  制限 ,  培養条件 ,  大腸菌 ,  グルコース代謝 ,  促進