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J-GLOBAL ID：201702219442122576   Reference number：17A0507161

The role of α4 integrin in Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease: an infectious animal model for multiple sclerosis (MS)

タイラーマウス脳脊髄炎ウイルス(TMEV)誘発性脱髄疾患におけるα4インテグリンの役割 多発性硬化症(MS)の感染動物モデル

Author (7)： HIRANO Yuta (Shinshu Univ., Nagano, JPN) ,  KOBAYASHI Kunitoshi (Shinshu Univ., Nagano, JPN) ,  TOMIKI Hiroki (Shinshu Univ., Nagano, JPN) ,  INABA Yuhji (Shinshu Univ., Nagano, JPN) ,  ICHIKAWA Motoki (Shinshu Univ., Nagano, JPN) ,  KIM Byung S. (Northwestern Univ. Feinberg Medical School, IL, USA) ,  KOH Chang-Sung (Shinshu Univ., Nagano, JPN)
Material： International Immunology  (Int Immunol)
Volume： 28  Issue： 12  Page： 575-584  Publication year： Dec. 2016 
JST Material Number： W0116A  ISSN： 0953-8178  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *demyelinating disease ,...
Semi thesaurus term： *HCA3551 ,...

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JST classification (2)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D) ,  Drugs acting on central nervous system in general  (GW03010A)

Reference (45)：

• Kebir, H., Kreymborg, K., Ifergan, I. et al. 2007. Human T_H 17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13:1173.
• Sospedra, M. and Martin, R. 2005. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23:683.
• Murray, P. D., Pavelko, K. D., Leibowitz, J., Lin, X. and Rodriguez, M. 1998. CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis. J. Virol. 72:7320.
• Tsunoda, I., Libbey, J. E., Kobayashi-Warren, M. and Fujinami, R. S. 2006. IFN-gamma production and astrocyte recognition by autoreactive T cells induced by Theiler's virus infection: role of viral strains and capsid proteins. J. Neuroimmunol 172:85.
• Pender, M. P. 2011. The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis. Neuroscientist 17:351.

Terms in the title (9)： タイラーマウス脳脊髄炎ウイルス ,  TMEV ,  脱髄疾患 ,  α4インテグリン ,  役割 ,  多発性硬化症 ,  感染 ,  動物 ,  モデル