Art

J-GLOBAL ID：201702220668043428   Reference number：17A1997911

The activated conformation of integrin β₇ is a novel multiple myeloma-specific target for CAR T cell therapy

免疫療法:インテグリンβ₇の活性型構造はCAR T細胞療法のための多発性骨髄腫特異的な新規標的である

Author (41)： HOSEN Naoki (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  HASEGAWA Kana (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  NAKAMURA Yuki (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  MAKITA Mio (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  WATANABE Kouki (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  YOSHIDA Mikako (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  SATOH Kei (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  OKA Yoshihiro (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  NISHIDA Sumiyuki (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  KUMANOGOH Atsushi (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  HOSEN Naoki (Osaka Univ., Osaka, JPN) ,  OKA Yoshihiro (Osaka Univ., Osaka, JPN) ,  TAKEDA Kiyoshi (Osaka Univ., Osaka, JPN) ,  KUMANOGOH Atsushi (Osaka Univ., Osaka, JPN) ,  MATSUNAGA Yukiko (Osaka Univ., Osaka, JPN) ,  TAKAGI Junichi (Osaka Univ., Osaka, JPN) ,  MATSUNO Hiroshi (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  NISHIMURA Junichi (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  MORIMOTO Soyoko (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  NAKATA Jun (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  TSUBOI Akihiro (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  FUJIKI Fumihiro (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  NAKAJIMA Hiroko (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  SUGIYAMA Haruo (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  MANABE Masahiro (Osaka General Hospital of West Japan Railway Co., Osaka, JPN) ,  ICHIHARA Hiroyoshi (Fuchu Hospital, Osaka, JPN) ,  AOYAMA Yasutaka (Fuchu Hospital, Osaka, JPN) ,  MUGITANI Atsuko (Fuchu Hospital, Osaka, JPN) ,  NAKAO Takafumi (Osaka City General Hospital, Osaka, JPN) ,  HINO Masayuki (Osaka City Univ. Graduate School of Medicine, Osaka, JPN) ,  UCHIBORI Ryosuke (Jichi Medical Univ., Tochigi, JPN) ,  OZAWA Keiya (Jichi Medical Univ., Tochigi, JPN) ,  OZAWA Keiya (Univ. Tokyo, Tokyo, JPN) ,  BABA Yoshihiro (Kyushu Univ., Fukuoka, JPN) ,  TERAKURA Seitaro (Nagoya Univ. Graduate School of Medicine, Nagoya, JPN) ,  WADA Naoki (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  MORII Eiichi (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  TAKEDA Kiyoshi (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  TAKEDA Kiyoshi (Japan Agency for Medical Res. and Dev.-Core Res. for Evolutional Sci. and Technol. (AMED-CREST), JPN) ,  KUMANOGOH Atsushi (Japan Agency for Medical Res. and Dev.-Core Res. for Evolutional Sci. and Technol. (AMED-CREST), JPN) ,  OJI Yusuke (Osaka Univ. Graduate School of Medicine, Osaka, JPN)
Material： Nature Medicine  (Nat Med)
Volume： 23  Issue： 12  Page： 1436-1443  Publication year： Dec. 2017 
JST Material Number： W0636A  ISSN： 1078-8956  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： immunotherapy ,  drug therapy ,  integrin ,  T cell ,  cell transplantation ,  multiple myeloma ,  antigen receptor ,  surface antigen ,  *monoclonal antibody ,  epitope ,  antitumor action
Semi thesaurus term： tumor immunotherapy ,  *インテグリンβ7 ,  *CAR T細胞 ,  CT ,  chimeric antigen receptor ,  Cell Surface Antigen ,  *MMG49

JST classification (3)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Tumor immunity  (ED03040A) ,  Immunotherapy for tumors  (GE03035B)

Terms in the title (6)： 免疫療法 ,  インテグリンβ7 ,  活性 ,  T細胞療法 ,  多発性骨髄腫 ,  標的