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J-GLOBAL ID：201702220858793508   Reference number：17A0802351

Tyrphostin AG-related compounds attenuate H₂O₂-induced TRPM2-dependent and -independent cellular responses

チロホスチンAG関連化合物はH₂O₂誘導TRPM2依存と独立細胞反応を軽減する

Author (6)： Yamamoto Shinichiro (Division of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, 164-8530, Japan) ,  Toda Takahiro (Division of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, 164-8530, Japan) ,  Yonezawa Ryo (Division of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, 164-8530, Japan) ,  Yonezawa Ryo (Department of Hospital Pharmaceutics, Showa University School of Pharmacy, Tokyo, 142-8555, Japan) ,  Negoro Takaharu (Division of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, 164-8530, Japan) ,  Shimizu Shunichi (Division of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, 164-8530, Japan)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 134  Issue： 1  Page： 68-74  Publication year： 2017 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Ion Channels ,...
Semi thesaurus term： *cell physiology ,...

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Author keywords (4)： Ca²⁺ ,  TRPM2 ,  AG-Related compounds ,  Hydroxyl radical

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Reference (34)：

• Hara Y, Wakamori M, Ishii M, et al. LTRPC2 Ca²⁺-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. 2002;9:163-173.
• Fonfria E, Marshall IC, Benham CD, et al. TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol. 2004;143:186-192.
• Buelow B, Song Y, Andrew M, Scharenberg AM. The poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem. 2008;283:24571-24583.
• Ishii M, Shimizu S, Hara Y, et al. Intracellular-produced hydroxyl radical mediates H₂O₂-induced Ca²⁺ influx and cell death in rat beta-cell line RIN-5F. Cell Calcium. 2006;39:487-494.
• Shimizu S, Yonezawa R, Negoro T, et al. Sensitization of H₂O₂-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe²⁺ in human monocytic U937 cells. Int J Biochem Cell Biol. 2015;68:119-127.

Terms in the title (5)： Ag ,  関連化合物 ,  H2O2 ,  誘導 ,  TRPM2