Shimizu Shunichi

Research field (2)： Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (2)： Pharmacology , Pathophysiology

Research theme for competitive and other funds (18)：

2015 - 2018 Localization and role of TRPM2 channel in the heart
2015 - 2018 転写因子FOXP3スプライシングバリアントの機能とアレルギー疾患への関与
2015 - 2017 腫瘍関連マクロファージ形成における低酸素及び活性酸素感受性TRPチャネルの関与
2012 - 2015 Attenuation of tumor growth in TRPM2 knockout mice and its mechanism
2009 - 2011 Aggravation mechanism of cardiac ischemia-reperfusion injury through oxidative stress-sensitive channel TRPM2

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Papers (52)：

Reiko Sakaguchi, Nobuaki Takahashi, Takashi Yoshida, Nozomi Ogawa, Yoshifumi Ueda, Satoshi Hamano, Kaori Yamaguchi, Seishiro Sawamura, Shinichiro Yamamoto, Yuji Hara, et al. Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals. The Journal of biological chemistry. 2024. 107705-107705
Shinichiro Yamamoto, Naoto Kiyatake, Akihiro Kaneko, Masanao Shimamura, Takashi Yoshida, Shunichi Shimizu. Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Masaaki Ishibashi, Masakazu Ishii, Shinichiro Yamamoto, Yasuo Mori, Shunichi Shimizu. Possible involvement of TRPM2 activation in 5-fluorouracil-induced myelosuppression in mice. European Journal of Pharmacology. 2021. 891. 173671-173671
Shinichiro Yamamoto, Takahiro Ishii, Ryota Mikami, Tomohiro Numata, Shunichi Shimizu. Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation. Biochemical and biophysical research communications. 2019. 520. 3. 520-525
Takahiro Toda, Shinichiro Yamamoto, Noriko Umehara, Yasuo Mori, Minoru Wakamori, Shunichi Shimizu. Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition. The Journal of pharmacology and experimental therapeutics. 2019. 368. 2. 246-254

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MISC (68)：

平松巴瑠香, 戸田雄大, 米澤龍, 根来孝治, 石井正和, 清水俊一. Tyrphostin AG化合物による活性酸素感受性Ca2+透過性チャネルTRPM2の活性化抑制. 日本薬学会年会要旨集. 2015. 135年会. 3. 179-179
市川瑞季, 石井正和, 加藤大貴, 栗原竜也, 河村満, 清水俊一. 片頭痛患者におけるバルプロ酸の抵抗性予測モデルの構築. 日本薬学会年会要旨集. 2014. 134年会. 4. 196-196
米澤龍, 竹中美貴, 賀家友紀子, 石井正和, 森泰生, 清水俊一. ブレオマイシンによる肺の炎症におけるTRPM2チャネルの役割. 日本薬学会年会要旨集. 2014. 134年会. 3. 138-138
石井正和, 加藤大貴, 栗原竜也, 河村満, 清水俊一. 片頭痛患者におけるロメリジンの反応性予測モデルの構築. 日本薬学会年会要旨集. 2013. 133年会. 4. 175-175
石井正和, 加藤大貴, 女屋朋美, 木内祐二, 笠井英世, 河村満, 清水俊一. 片頭痛患者と薬物乱用頭痛患者の生活習慣の違い. 日本薬学会年会要旨集. 2012. 132年会. 4. 259-259

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Education (4)：

- 1986 Showa University Pharmaceutical Scientific Research Division
- 1986 Showa University Graduate School, Division of Pharmaceutical Sciences
- 1984 Showa University School of Pharmacy
- 1984 Showa University Faculty of Pharmaceutical Science

Committee career (1)：

日本薬理学会評議員

Association Membership(s) (3)：

日本薬学会 , 日本薬理学会 , 日本生化学会

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